Active transport processes are now recognized as important determinants of drug absorption
and elimination. The role of the MDR1 gene product P-glycoprotein for drug disposition in …

The MDR1 gene product P-glycoprotein does not only contribute to drug resistance during
chemotherapy of tumors but it is also expressed in healthy tissues with excretory function …

P-glycoprotein is an ATP-dependent efflux pump that contributes to the protection of the
body from environmental toxins. It transports a huge variety of structurally diverse …

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

The human multidrug resistance gene (MDR1), spanning greater than 200 kb, encodes for
the ATP-dependent membrane efflux transporter, P-glycoprotein (Pgp). Significant progress …

Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance
against antineoplastic agents but also plays an important role in the bioavailability of …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

In humans, there are two P-glycoprotein (P-gp) transporters encoded by MDR1 (PGY1) and
MDR3 (also named MDR2 and PGY3) adjacently located at the chromosomal region 7q21 …

P-glycoprotein (PGP) is a membrane protein which determines drug disposition in humans
(eg digoxin). It is also expressed in various leukocyte lineages with highest expression in …

Abstract P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as
an energy-dependent efflux pump that exports its substrates out of the cell. PGP expression …