It remains elusive whether some of the associations identified in genome-wide association
studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on …

Genome-wide association studies have identified more than 100 SNPs that increase the risk
of prostate cancer (PrCa). We identify and compare expression quantitative trait loci (eQTLs) …

DNA methylation plays important roles in prostate cancer (PCa) development and
progression. African American men have higher incidence and mortality rates of PCa than …

Background Aberrant DNA methylation may promote prostate carcinogenesis. We
investigated epigenome‐wide DNA methylation profiles in prostate cancer (PCa) compared …

Although prostate cancer (PCa) is the second leading cause of cancer death among men
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …

Background Promoter and 5′ end methylation regulation of tumour suppressor genes is a
common feature of many cancers. Such occurrences often lead to the silencing of these key …

Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …

Increasing evidence suggests that aberrant DNA methylation changes may contribute to
prostate cancer (PCa) ethnic disparity. To comprehensively identify DNA methylation …

A large proportion of heritability for prostate cancer risk remains unknown. Transcriptome‐
wide association study combined with validation comparing overall levels will help to identify …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …