DNA methylation markers for risk of metastasis in a cohort of men with localized prostate cancer
TS Habeshian, KL Cannavale, JM Slezak, YH Shu… - Epigenetics, 2024 - Taylor & Francis
Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an
unsolved problem. We evaluated whether DNA methylation status of selected candidate …
unsolved problem. We evaluated whether DNA methylation status of selected candidate …
Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms
Here we train cis-regulatory models of prostate tissue gene expression and impute
expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer …
expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer …
Genomic DNA methylation-derived algorithm enables accurate detection of malignant prostate tissues
E Aref-Eshghi, LC Schenkel, P Ainsworth, H Lin… - Frontiers in …, 2018 - frontiersin.org
Introduction The current methodology involving diagnosis of prostate cancer (PCa) relies on
the pathology examination of prostate needle biopsies, a method with high false negative …
the pathology examination of prostate needle biopsies, a method with high false negative …
Random forest-based modelling to detect biomarkers for prostate cancer progression
R Toth, H Schiffmann, C Hube-Magg, F Büscheck… - Clinical …, 2019 - Springer
Background The clinical course of prostate cancer (PCa) is highly variable, demanding an
individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not …
individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not …
DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk
Developmental exposure to endocrine-disrupting chemicals (EDCs), 17β-estradiol-3-
benzoate (EB) and bisphenol A (BPA), increases susceptibility to prostate cancer (PCa) in …
benzoate (EB) and bisphenol A (BPA), increases susceptibility to prostate cancer (PCa) in …
Genome-wide methylation analysis identifies involvement of TNF-α mediated cancer pathways in prostate cancer
SJ Kim, WK Kelly, A Fu, K Haines, A Hoffman, T Zheng… - Cancer letters, 2011 - Elsevier
Altered signaling pathways resulting from aberrant changes in epigenetic parameters may
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …
Genome-wide DNA methylation model for the diagnosis of prostate cancer
JB Nikas, EG Nikas - ACS omega, 2019 - ACS Publications
Prostate cancer is the most prevalent and the second most lethal malignancy among males
in the United States of America. Its diagnosis is almost entirely predicated upon …
in the United States of America. Its diagnosis is almost entirely predicated upon …
The genomic impact of DNA CpG methylation on gene expression; relationships in prostate cancer
The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …
and revealed associations between changing methylation status of CpG islands and gene …
Prostate cancer genomics, biology, and risk assessment through genome‐wide association studies
H Nakagawa, S Akamatsu, R Takata… - Cancer …, 2012 - Wiley Online Library
Prostate cancer (PC) is the most common malignancy observed in men. It is evident that
genetic factors play some important roles in PC etiology. Recently, genome‐wide …
genetic factors play some important roles in PC etiology. Recently, genome‐wide …
Functional annotation of risk loci identified through genome‐wide association studies for prostate cancer
BACKGROUND The majority of established prostate cancer (PCa) risk‐associated single
nucleotide polymorphisms (SNPs) identified from genome‐wide association studies do not …
nucleotide polymorphisms (SNPs) identified from genome‐wide association studies do not …