Accurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an
unsolved problem. We evaluated whether DNA methylation status of selected candidate …

Here we train cis-regulatory models of prostate tissue gene expression and impute
expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer …

Introduction The current methodology involving diagnosis of prostate cancer (PCa) relies on
the pathology examination of prostate needle biopsies, a method with high false negative …

Background The clinical course of prostate cancer (PCa) is highly variable, demanding an
individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not …

Developmental exposure to endocrine-disrupting chemicals (EDCs), 17β-estradiol-3-
benzoate (EB) and bisphenol A (BPA), increases susceptibility to prostate cancer (PCa) in …

Altered signaling pathways resulting from aberrant changes in epigenetic parameters may
play a pivotal role in carcinogenesis. To identify biological pathways likely to be affected by …

Prostate cancer is the most prevalent and the second most lethal malignancy among males
in the United States of America. Its diagnosis is almost entirely predicated upon …

The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …

Prostate cancer (PC) is the most common malignancy observed in men. It is evident that
genetic factors play some important roles in PC etiology. Recently, genome‐wide …

BACKGROUND The majority of established prostate cancer (PCa) risk‐associated single
nucleotide polymorphisms (SNPs) identified from genome‐wide association studies do not …