The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice
V Bieghs, T Hendrikx, PJ van Gorp, F Verheyen… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Non-alcoholic steatohepatitis is characterized by hepatic steatosis
with inflammation. Although steatosis is benign and reversible, inflammation can increase …
with inflammation. Although steatosis is benign and reversible, inflammation can increase …
Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr−/− mice
T Hendrikx, MLJ Jeurissen, V Bieghs… - Journal of …, 2015 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) is characterized by hepatic lipid
accumulation and inflammation. Currently, the underlying mechanisms, leading to hepatic …
accumulation and inflammation. Currently, the underlying mechanisms, leading to hepatic …
Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
V Bieghs, K Wouters, PJ Van Gorp, MJJ Gijbels… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a disorder that consists of
steatosis and hepatic inflammation. It is not known why only some people with steatosis …
steatosis and hepatic inflammation. It is not known why only some people with steatosis …
[HTML][HTML] Oxysterol 7-α hydroxylase (CYP7B1) attenuates metabolic-associated fatty liver disease in mice at thermoneutrality
I Evangelakos, D Schwinge, A Worthmann, C John… - Cells, 2021 - mdpi.com
Ambient temperature is an important determinant of both the alternative bile acid synthesis
pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic …
pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic …
[HTML][HTML] Cholesterol accumulation as a driver of hepatic inflammation under translational dietary conditions can be attenuated by a multicomponent medicine
AM Mueller, R Kleemann, E Gart… - Frontiers in …, 2021 - frontiersin.org
Background Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder
that is characterised by dysfunctional lipid metabolism and cholesterol homeostasis, and a …
that is characterised by dysfunctional lipid metabolism and cholesterol homeostasis, and a …
[HTML][HTML] Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells
V Bieghs, F Verheyen, PJ van Gorp, T Hendrikx… - PloS one, 2012 - journals.plos.org
Background & Aims Non-alcoholic steatohepatitis (NASH) is characterized by steatosis and
inflammation, which can further progress into fibrosis and cirrhosis. Recently, we …
inflammation, which can further progress into fibrosis and cirrhosis. Recently, we …
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
T Teratani, K Tomita, T Suzuki, T Oshikawa… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Some studies have indicated that dietary cholesterol has a role in
the progression of liver fibrosis. We investigated the mechanisms by which dietary …
the progression of liver fibrosis. We investigated the mechanisms by which dietary …
[HTML][HTML] Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
G Lorbek, M Perše, J Jeruc, P Juvan… - Scientific reports, 2015 - nature.com
We demonstrate unequivocally that defective cholesterol synthesis is an independent
determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific …
determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific …
[HTML][HTML] Dietary oxysterol, 7-ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese mice
J Chang, M Koseki, A Saga, K Kanno, T Higo… - Frontiers in …, 2021 - frontiersin.org
Non-alcoholic fatty liver disease is strongly associated with obese and type 2 diabetes. It has
been reported that an oxidized cholesterol, 7-ketocholesterol (7KC), might cause …
been reported that an oxidized cholesterol, 7-ketocholesterol (7KC), might cause …
[HTML][HTML] Hepatic reduction in cholesterol 25-hydroxylase aggravates diet-induced steatosis
Z Dong, F He, X Yan, Y Xing, Y Lei, J Gao, M He… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-
hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti …
hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti …