The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …

Tight junctions are important for skin barrier function. The tight junction protein claudin 1
(Cldn-1) has been reported to be down-regulated in nonlesional skin of atopic dermatitis …

Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently
noted that the characteristics of epidermal barrier functions critically influence the …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier
function of simple epithelia, but TJs have not been thought to play an important role in the …

Tight junction (TJ) proteins are known to be involved in proliferation and differentiation.
These processes are essential for normal skin wound healing. Here, we investigated the TJ …

Tight junctions (TJ) are cell–cell junctions that have proved to form a paracellular barrier for
solutes and water between cells of epithelia, including the stratum granulosum of the …

Background The tight junction (TJ) barrier is located in the granular layer of the epidermis.
Filaggrin deficiency predisposes patients to atopic dermatitis (AD) by impairing stratum …

BACKGROUND: Tight junctions (TJs) contribute to the epithelial barrier function by
preventing leakage of solutes through the intercellular space. In the skin, TJs occur in the …

Tight junction (TJ) dysfunction in the stratum granulosum leads to aberrant barrier function of
the stratum corneum (SC) in the epidermis. However, it is unclear whether TJs are perturbed …