Abstract Background Tight junctions (TJs) have important roles in skin barrier function. The
TJ protein claudin-1 (CLDN1) is decreased in atopic dermatitis (AD). However, little is known …

In epithelia, tight junctions (TJs) create a primary barrier to the diffusion of solutes through
the paracellular pathway. Although TJ-related molecules are present in the epidermis, the …

Tight junctions (TJ) are barrier forming cell–cell junctions that are found in a variety of cell
types and tissues but their existence in mammalian epidermis has been shown only in the …

Barrier function of hair follicles (HFs) is of great interest because they might be an entry port
for allergens/pathogens, but could on the other hand be used for drug delivery or …

Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of
epidermal barrier function. This correlates with the loss of apical polarization of lamellar …

The epidermis has developed physical and immunological barriers that prevent infiltration of
deleterious chemicals and pathogens. As a first step to understanding the relationship …

Epithelial tight junctions play a central role in cell–cell adhesion and are necessary for the
selective paracellular movement of ions. Claudins are key components of tight junctions and …

Tight junctions (TJs) form a selective barrier for ions, water, and macromolecules in simple
epithelia. In keratinocytes and epidermis, TJs were shown to be involved in individual barrier …

Atopic dermatitis (AD) is characterized by epidermal tight junction (TJ) defects and a
propensity for Staphylococcus aureus skin infections. S. aureus is sensed by many pattern …

Tight junctions (TJs) are complex cell-cell junctions that form a barrier in the stratum
granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other …