Using drugs to target necroptosis: dual roles in disease therapy

Z Wang, LM Guo, SC Wang, FX Liu, D Chen, JF Huang… - 2018 - digitum.um.es
Necroptosis is programmed necrosis, a process which has been studied for over a decade.
The most common accepted mechanism is through the RIP1-RIP3-MLKL axis to regulate …

[HTML][HTML] The potential role of necroptosis in clinical diseases

W Dai, J Cheng, X Leng, X Hu… - … Journal of Molecular …, 2021 - spandidos-publications.com
As an important type of programmed cell death in addition to apoptosis, necroptosis occurs
in a variety of pathophysiological processes, including infections, liver diseases, kidney …

Necroptosis inhibitors: mechanisms of action and therapeutic potential

Y Zhou, Z Cai, Y Zhai, J Yu, Q He, Y He, S Jitkaew… - Apoptosis, 2024 - Springer
Necroptosis is a type of programmed cell death that is morphologically similar to necrosis.
This type of cell death is involved in various pathophysiological disorders, including …

[HTML][HTML] A Glimpse of necroptosis and diseases

M Yang, W Chen, L He, D Liu, L Zhao… - Biomedicine & …, 2022 - Elsevier
Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a
type of programmed cell death that has been recently discovered. It is mediated by RIPK1 …

Small-molecule inhibitors of necroptosis: current status and perspectives

C Zhuang, F Chen - Journal of Medicinal Chemistry, 2019 - ACS Publications
Necroptosis, an important form of programmed cell death (PCD), is a highly regulated
caspase-independent type of cell death that plays a critical role in the pathophysiology of …

The role of necroptosis in disease and treatment

X Liu, X Xie, Y Ren, Z Shao, N Zhang, L Li, X Ding… - MedComm, 2021 - Wiley Online Library
Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis,
triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1) …

[HTML][HTML] Molecular insights into the mechanism of necroptosis: the necrosome as a potential therapeutic target

J Chen, R Kos, J Garssen, F Redegeld - Cells, 2019 - mdpi.com
Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …

[HTML][HTML] Cancer therapy in the necroptosis era

Z Su, Z Yang, L Xie, JP DeWitt, Y Chen - Cell Death & Differentiation, 2016 - nature.com
Necroptosis is a caspase-independent form of regulated cell death executed by the receptor-
interacting protein kinase 1 (RIP1), RIP3, and mixed lineage kinase domain-like protein …

Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases

PA Dionísio, JD Amaral, CMP Rodrigues - International Review of Cell and …, 2020 - Elsevier
Necroptosis is a regulated cell death pathway morphologically similar to necrosis that
depends on the kinase activity of receptor interacting protein 3 (RIP3) and the subsequent …

[HTML][HTML] The role of necroptosis: biological relevance and its involvement in cancer

L Della Torre, A Nebbioso, HG Stunnenberg… - Cancers, 2021 - mdpi.com
Simple Summary A new form of programmed necrosis called necroptosis has emerged. This
new and well-documented type of programmed cell death is involved in several human …