The protective role of interleukin-6 monoclonal antibody on experimental autoimmune myocarditis and its mechanism

S He, LN Han, YT Wang, JW Liu… - … Ying Yong Sheng li xue za …, 2014 - europepmc.org
Objective To investigate the therapeutic effect of IL-6 mAb on experimental autoimmune
myocarditis (EAM) in rats, and search the mechanism of the role of IL-6, helper T cells 17 …

Immune state of Th1, Th2 and Th17 subpopulation in experimental autoimmune myocarditis

LN Han, TL Li, YJ Zhang, TS Yang, Y Ding… - … da xue xue bao. Yi xue …, 2011 - europepmc.org
OBJECTIVE: To shed light on changes in the gene expression of T helper lymphocyte (Th)
subpopulation, Th1, Th2 and Th17 in autoimmune myocarditis and to gain insight into the …

Time course of interleukin-21 and related cytokines expression in rats with experimental autoimmune myocarditis

Y Wang, G Li, JX Tang, H Chang - Zhonghua xin xue Guan Bing za …, 2012 - europepmc.org
Objective To observe the time course of interleukin (IL)-21 and related cytokines expression
in rats with experimental autoimmune myocarditis (EAM). Methods Antigen was prepared …

Protective effect and mechanism of IL-17 monoclonal antibody on mice with viral myocarditis

H Qian, L Liu - Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal …, 2014 - europepmc.org
Objective To explore the protective effects of interleukin-17 monoclonal antibody (IL-17
mAb) on viral myocarditis (VMC) mice and its possible molecular mechanisms. Methods …

Recombinant murine interleukin-12 facilitates induction of cardiac myosin–specific type 1 helper T cells in rats

Y Okura, K Takeda, S Honda, H Hanawa… - Circulation …, 1998 - Am Heart Assoc
Autoimmunity after viral myocarditis is considered to be one of the causes of dilated
cardiomyopathy. Cytokines are assumed to play an important role in the pathogenesis. We …

Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats

W Li, LIU Wei, GAO Cheng, B Zhou, S Yang… - Chinese medical …, 2006 - journals.lww.com
Background Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated
disorder. The initiation and maintenance of autoimmune responses in EAM depend on the …

Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer

HE Chang, H Hanawa, T Yoshida, M Hayashi… - Circulation …, 2008 - jstage.jst.go.jp
Background T-helper (Th) 1/Th2 cytokine balance plays an important role in the
pathogenesis of myocarditis. Recently, some studies indicate that interleukin (IL)-17, known …

Effect of intravenous immunoglobulin and vitamin C on progression of experimental autoimmune myocarditis in mice

YF Hu, FQ Gong, LQ Chen, WZ Gu - Zhejiang da xue xue bao. Yi …, 2008 - europepmc.org
Objective To evaluate the effect of intravenous immunoglobulin (IVIG) and vitamin C on the
progression of experimental autoimmune myocarditis (EAM). Methods Fifty-two Balb/c mice …

IL-10 gene modified dendritic cells induced antigen-specific tolerance in experimental autoimmune myocarditis

S Yang, W Li, W Liu, C Gao, B Zhou, S Li, Y Li… - Clinical …, 2006 - Elsevier
Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder, and the
involvement of Th1/Th2 unbalance has been demonstrated. The induction of antigen …

Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis

M Shao, D Wang, Y Zhou, K Du, W Liu - International …, 2020 - Elsevier
Backgrounds Autoimmune myocarditis is characterized by over-activated immune system
attacking the cardiomyocytes, resulting in heart function decline. In the current study, we …