The potential harmful effects of polypharmacy (concurrent use of 5 or more drugs) are
difficult to investigate in an experimental design in humans. Moreover, there is a lack of …

A major challenge in the health care system is the lack of knowledge about the possible
harmful effects of multiple drug treatments in old age. The present study aims to characterize …

Males and females may respond differently to medications, yet knowledge about sexual
dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study …

Aging, polypharmacy (concurrent use of≥ 5 medications), and functional impairment are
global healthcare challenges. However, knowledge of the age/sex-specific effects of …

We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-
term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated …

Although previous research has linked polypharmacy to lower cognitive function in the
general population, we know little about this association among economically challenged …

Cocaine and ethanol are two commonly co-abused substances; however, the
neuropathology following chronic dual consumption is poorly understood. Neural stem cells …

The process of aging, biologically speaking, involves changes in molecular, cellular, and
physiological processes over the life course of an individual that lead to losses in functional …

Age-dependent cognitive decline is associated with a downregulation of the cyclic
nucleotide cascade. Through their regulation of the cGMP pathway, phosphodiesterase 5 …

Rationale Recreational and medical use of stimulants is increasing, and their use may
increase susceptibility to aging and promote neurobehavioral impairments. The long-term …