Tobacco smoking-associated alterations in the immune microenvironment of squamous cell carcinomas
A Desrichard, F Kuo, D Chowell, KW Lee… - JNCI: Journal of the …, 2018 - academic.oup.com
Background Tobacco smoking creates DNA damage, inducing mutations and potentially
altering the tumor immune microenvironment. These types of genetic and immune …
altering the tumor immune microenvironment. These types of genetic and immune …
Molecular techniques and genetic alterations in head and neck cancer
PK Ha, SS Chang, CA Glazer, JA Califano, D Sidransky - Oral oncology, 2009 - Elsevier
It is well known that cellular DNA alterations can lead to the formation of cancer, and there
has been much discovery in the pathways involved in the development of head and neck …
has been much discovery in the pathways involved in the development of head and neck …
NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents
C Pan, S Izreig, WG Yarbrough, N Issaeva - Cancers of the Head & Neck, 2019 - Springer
Background Compared to HPV-negative head and neck squamous cell carcinomas
(HNSCCs), HPV-positive HNSCCs are associated with a favorable prognosis in part due to …
(HNSCCs), HPV-positive HNSCCs are associated with a favorable prognosis in part due to …
The mutational landscape of head and neck squamous cell carcinoma
N Stransky, AM Egloff, AD Tward, AD Kostic… - science, 2011 - science.org
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome …
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome …
[HTML][HTML] The degree of intratumor mutational heterogeneity varies by primary tumor sub-site
LG Ledgerwood, D Kumar, AK Eterovic, J Wick… - Oncotarget, 2016 - ncbi.nlm.nih.gov
In an era where mutational profiles inform treatment options, it is critical to know the extent to
which tumor biopsies represent the molecular profile of the primary and metastatic tumor …
which tumor biopsies represent the molecular profile of the primary and metastatic tumor …
Genomic insights into head and neck cancer
TN Beck, EA Golemis - Cancers of the head & neck, 2016 - Springer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers …
worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers …
Sequencing the head and neck cancer genome: implications for therapy
W Sun, JA Califano - Annals of the New York Academy of …, 2014 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) is a disease with significant morbidity
and mortality. The advancement of next‐generation sequencing technologies now enables …
and mortality. The advancement of next‐generation sequencing technologies now enables …
Unraveling molecular mechanisms of head and neck cancer
P Parashar, H Hungyo, A Jain, S Ahmad… - Critical reviews in …, 2022 - Elsevier
Malignancies that develop from mucosal epithelium of the upper aerodigestive tract are
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …
Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients
Y Kim, PS Hammerman, J Kim, J Yoon… - Journal of clinical …, 2014 - ascopubs.org
Purpose Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung
cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely …
cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely …
High level of tobacco carcinogen–derived DNA damage in oral cells is an independent predictor of oral/head and neck cancer risk in smokers
SS Khariwala, B Ma, C Ruszczak, SG Carmella… - Cancer Prevention …, 2017 - AACR
Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons
(PAH) is recognized to play an important role in the development of oral/head and neck …
(PAH) is recognized to play an important role in the development of oral/head and neck …