Background Tobacco smoking creates DNA damage, inducing mutations and potentially
altering the tumor immune microenvironment. These types of genetic and immune …

It is well known that cellular DNA alterations can lead to the formation of cancer, and there
has been much discovery in the pathways involved in the development of head and neck …

Background Compared to HPV-negative head and neck squamous cell carcinomas
(HNSCCs), HPV-positive HNSCCs are associated with a favorable prognosis in part due to …

Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome …

In an era where mutational profiles inform treatment options, it is critical to know the extent to
which tumor biopsies represent the molecular profile of the primary and metastatic tumor …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers …

Head and neck squamous cell carcinoma (HNSCC) is a disease with significant morbidity
and mortality. The advancement of next‐generation sequencing technologies now enables …

Malignancies that develop from mucosal epithelium of the upper aerodigestive tract are
known as head and neck squamous cell carcinomas (HNSCC). Heterogeneity, late stage …

Purpose Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung
cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely …

Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons
(PAH) is recognized to play an important role in the development of oral/head and neck …