[HTML][HTML] Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance

N Batta, M Pandey - World Journal of Surgical Oncology, 2019 - Springer
Oral squamous cell cancer (OSCC) is a common malignancy attributed to use of chewing
smokeless tobacco and smoking. Most of the targeted strategies are based on EGFR …

Smoking-related genomic signatures in non–small cell lung cancer

PP Massion, Y Zou, H Chen, A Jiang… - American journal of …, 2008 - atsjournals.org
Rationale: Tobacco smoking is responsible for 85% of all lung cancers. To further our
understanding of the molecular pathogenesis of lung cancer, we determined whether …

[HTML][HTML] Tongue carcinoma infrequently harbor common actionable genetic alterations

DSW Tan, W Wang, HS Leong, PH Sew, DP Lau… - BMC cancer, 2014 - Springer
Background Oral tongue squamous cell carcinomas (TSCC) are a unique subset of head
and neck cancers with a distinct demographic profile, where up to half of the cases are never …

[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy

CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

[HTML][HTML] Smoking and lung cancer: a geo-regional perspective

Z Rahal, S El Nemr, A Sinjab, H Chami, A Tfayli… - Frontiers in …, 2017 - frontiersin.org
Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung
cancer (NSCLC) represents the most frequently diagnosed subtype of this morbid …

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

Y Wang, S Springer, CL Mulvey, N Silliman… - Science translational …, 2015 - science.org
To explore the potential of tumor-specific DNA as a biomarker for head and neck squamous
cell carcinomas (HNSCC), we queried DNA from saliva or plasma of 93 HNSCC patients …

Reduced DNA repair capacity for removing tobacco carcinogen–induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics

LE Wang, Z Hu, EM Sturgis, MR Spitz, SS Strom… - Clinical cancer …, 2010 - AACR
Purpose: Although cigarette smoking and alcohol use are known risk factors for squamous
cell carcinoma of head and neck (SCCHN), only a few exposed individuals develop this …

Molecular and cellular alterations in tobacco smoke-associated larynx cancer

K Szyfter, Z Szmeja, W Szyfter, K Hemminki… - … /Genetic Toxicology and …, 1999 - Elsevier
Tumours of head and neck belong to the most frequent types of cancer world-wide. In
Poland, mortality from larynx cancer among males has been continuously increasing during …

[HTML][HTML] Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing: A prospective …

AP Zammit, R Sinha, CL Cooper, CFL Perry, IH Frazer… - PLoS …, 2018 - journals.plos.org
Oral cavity Squamous Cell Carcinoma (OCSCC) is a common form of head and neck cancer
throughout the developed and developing world. However, the etiology of OCSCC is still …

Cytogenetic alterations and their molecular genetic correlates in head and neck squamous cell carcinoma: a next generation window to the biology of disease

SM Gollin - Genes, Chromosomes and Cancer, 2014 - Wiley Online Library
Cytogenetic alterations underlie the development of head and neck squamous cell
carcinoma (HNSCC), whether tobacco and alcohol use, betel nut chewing, snuff or human …