Somatic mutations in tumor and plasma of locoregional recurrent and/or metastatic head and neck cancer using a next‐generation sequencing panel: A preliminary …

Ó Rapado‐González, J Brea‐Iglesias… - Cancer …, 2023 - Wiley Online Library
Background We explore the utility of TruSight Tumor 170 panel (TST170) for detecting
somatic mutations in tumor and cfDNA from locoregional recurrent and/or metastatic head …

Whole-exome sequencing analysis of oral squamous cell carcinoma delineated by tobacco usage habits

K Patel, FA Bhat, S Patil, S Routray, N Mohanty… - Frontiers in …, 2021 - frontiersin.org
Oral squamous cell carcinoma (OSCC) is a common cancer of the oral cavity in India.
Cigarette smoking and chewing tobacco are known risk factors associated with OSCC …

TP53 mutations in head and neck cancer

CA Nathan, AR Khandelwal, GT Wolf… - Molecular …, 2022 - Wiley Online Library
Head and neck squamous cell carcinomas (HNSCCs) arising in the mucosal linings of the
upper aerodigestive tract are highly heterogeneous, aggressive, and multifactorial tumors …

[HTML][HTML] Ancestral-derived effects on the mutational landscape of laryngeal cancer

MP Ramakodi, RJ Kulathinal, Y Chung, I Serebriiskii… - Genomics, 2016 - Elsevier
Laryngeal cancer disproportionately affects more African-Americans than European-
Americans. Here, we analyze the genome-wide somatic point mutations from the tumors of …

Genomic landscape of head and neck squamous cell carcinoma across different anatomic sites in Chinese population

Y Ju, X Wu, H Wang, B Li, Q Long, D Zhang… - Frontiers in …, 2021 - frontiersin.org
Background The characteristics of head and neck squamous cell carcinoma (HNSCC)
across different anatomic sites in the Chinese population have not been studied. To …

Tumor evolution and intratumor heterogeneity of an oropharyngeal squamous cell carcinoma revealed by whole-genome sequencing

XC Zhang, C Xu, RM Mitchell, B Zhang, D Zhao, Y Li… - Neoplasia, 2013 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic
instability that could lead to clonal diversity. Intratumor clonal heterogeneity has been …

Comparing genomic landscapes of oral and cutaneous squamous cell carcinoma of the head and neck: quest for novel diagnostic markers

R Gupta, D Strbenac, L Satgunaseelan, VKY Cheung… - Modern Pathology, 2023 - Elsevier
Squamous cell carcinoma is the most common head and neck malignancy arising from the
oral mucosa and the skin. The histologic and immunohistochemical features of oral …

Smoking and smokeless tobacco-associated human buccal cell mutations and their association with oral cancer—a review

NK Proia, GM Paszkiewicz, MA Sullivan Nasca… - … Biomarkers & Prevention, 2006 - AACR
Reported herein are the results of a structured literature review that was undertaken to (a)
determine if human buccal (mouth) cell changes are associated with smoking and …

All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia …

HAJ Kim, PYF Zeng, MH Shaikh, N Mundi, F Ghasemi… - Oral Oncology, 2021 - Elsevier
Purpose Head and neck squamous cell carcinoma (HNSCC) affects various anatomical
sites, which often dictates whether the cancer is managed with primary surgery or radiation …

Genetic landscape of human papillomavirus–associated head and neck cancer and comparison to tobacco-related tumors

DN Hayes, C Van Waes, TY Seiwert - Journal of clinical oncology, 2015 - ascopubs.org
Head and neck cancer is the fifth most common cancer worldwide. It is often amenable to
curative intent therapy when localized to the head and neck region, but it carries a poor …