Interindividual variation in the expression of tumor necrosis factor α (TNF) suggests the
existence of functionally distinct TNF alleles that could play a role in susceptibility to TNF …

In this paper the functional relevance of a TNFA promoter polymorphism, a G/A polymorphic
sequence at position-238, was tested by analysing its influence on TNFα production upon …

Tumour necrosis factor-alpha (TNF-alpha) is a potent immunomediator and proinflammatory
cytokine that has been implicated in the pathogenesis of a large number of human diseases …

In human monocytic cell lines, tumor necrosis factor α (TNFα) expression is induced by
phorbol myrlstate acetate (PMA). We have identified positive and negative cls-acting …

We present a map of single nucleotide polymorphisms (SNPs) in the human tumor necrosis
factor (TNF)-α promoter based upon exploratory sequencing of 333 human TNF-α gene …

The authors have previously demonstrated that the tumour necrosis factor (TNF)− 308 G/A
polymorphism affects the binding of transcription factors. In transient transfection assays in …

TNF‐α is involved in infectious and immuno‐inflammatory diseases. Different individuals
may have different capacities for TNF‐α production. This might determine a predisposition to …

TNF‐α is a proinflammatory cytokine that has been implicated in the severity of different
immune‐regulated diseases including autoimmune diseases and transplantation. The gene …

TNF genes determine strength, effectiveness, and duration of local and systemic
inflammatory reactions, as well as repair and recovery from infectious and toxic agents …

Tumor necrosis factor (TNF, originally cachectin or TNF-a) is the prototype member of a
large family of proteins with diverse functions including induction of apoptosis and regulation …