Transcription of the TNF gene is rapidly and transiently induced by LPS in cells of monocyte/
macrophage lineage. Previous data suggested that multiple NF-κB/Rel binding sites play a …

We describe a dense cluster of DNA-protein interactions located 600 nucleotides upstream
of the transcriptional start site of the human tumor necrosis factor (TNF) gene. This area was …

Polymorphism of the 5′‐flanking promoter/enhancer region of the TNF‐α gene in Japanese
is not well understood. To better understand it, we have determined the 1,358 base pair …

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in
the pathogenesis of several diseases. Its encoding gene is located in the short arm of …

The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of
the tumour necrosis factor alpha (TN Fα) gene in patients with rheumatoid arthritis (RA) and …

Objective. The polymorphic tumor necrosis factor α (TNFα) gene encodes a cytokine
involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is …

Background Functional heterogeneity in the tumor necrosis factor α (TNF-α) gene may be
responsible for the TNF-α response in infectious and autoimmune diseases. Recently, the …

Source/Description: Sequencing of the 5'-region (-595 to+ 390) of the human TNFa gene
revealed a G to A transition polymorphism at position—308 (1). An oligonucleotide was …

Transcription of the tumor necrosis factor (TNF) gene is rapidly and transiently induced by
lipopolysaccharide in cells of monocyte/macrophage lineage. Previous studies have …

Distinctions between tumor necrosis factor, TNF-α, and lymphotoxin, TNF-β, have previously
been based on the differences between their protein sequences, biological activity, and …