We have investigated the association between alleles of the genes for tumour necrosis
factor-alpha (TNF-α) and TNF-β and severity of disease during malarial (Plasmodium …

Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting
human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes …

Tumor necrosis factor and lymphotoxin, also termed TNF-c~ and TNF-~(Nedwin et al.
1985a), are polypeptides secreted by peripheral blood leukocytes (PBLs). Their production …

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc)
within a 12-kilobase region of the human major histocompatibility complex (MHC) that …

One of the greatest challenges facing genetics is the development of strategies to identify
functionally relevant genetic variation. The most common test of function is the reporter gene …

The cytokine TNF is a critical mediator of immune and inflammatory responses. The TNF
gene is an immediate early gene, rapidly transcribed in a variety of cell types following …

The cytokine TNF-[alpha] has been implicated in the pathogenesis of both acute and chronic
transplant rejection. Levels of the cytokine are known to vary in a normal population, leading …

We have identified a region of the human tumor necrosis factor alpha (TNF-alpha) gene
promoter that is necessary for maximal constitutive, virus-induced, and lipopolysaccharide …

The Tumor Necrosis Factor-alpha (TNF-α) is a pleiotropic cytokine that produces different
stimuli in various physiological and pathological conditions. TNF-α contributes importantly to …

Tumor necrosis factor-α (TNFα) is a pivotal early mediator of host defenses that is essential
for survival in infections. We previously reported that exposing macrophages to febrile range …