A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor α gene expression: molecular cloning, sequencing, characterization, and …
F Myokai, S Takashiba, R Lebo… - Proceedings of the …, 1999 - National Acad Sciences
Lipopolysaccharide (LPS) is a potent stimulator of monocytes and macrophages, causing
secretion of tumor necrosis factor α (TNF-α) and other inflammatory mediators. Given the …
secretion of tumor necrosis factor α (TNF-α) and other inflammatory mediators. Given the …
A Th1-associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood-stage malaria in mice
P Jacobs, D Radzioch, MM Stevenson - Infection and immunity, 1996 - Am Soc Microbiol
We investigated the kinetics of tissue-specific mRNA expression and systemic production of
tumor necrosis factor alpha (TNF-alpha) and the kinetics of splenic expression of mRNAs of …
tumor necrosis factor alpha (TNF-alpha) and the kinetics of splenic expression of mRNAs of …
Tumor necrosis factor‐α promoter variant 2 (TNF2) is associated with pre‐term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort …
M Aidoo, PD McElroy, MS Kolczak… - … Official Publication of …, 2001 - Wiley Online Library
A polymorphism in the promoter region of the tumor necrosis factor‐α (TNF‐α) gene, with a
guanine to adenine nucleotide change at position–308, TNF2 is associated with increased …
guanine to adenine nucleotide change at position–308, TNF2 is associated with increased …
Genomic structure, induction, and production of TNF-alpha.
DR Spriggs, S Deutsch, DW Kufe - Immunology series, 1992 - europepmc.org
The TNF gene is located in close proximity to the HLA-B locus in both humans and mouse.
TNF has a high degree of sequence observation across species, and this is reflected in its …
TNF has a high degree of sequence observation across species, and this is reflected in its …
Interethnic differences in the association of tumor necrosis factor promoter polymorphisms with systemic lupus erythematosus.
M Rudwaleit, M Tikly, M Khamashta… - The Journal of …, 1996 - europepmc.org
Objective To assess the role of polymorphisms in the promoter region of the tumor necrosis
factor-alpha (TNF-alpha) gene in susceptibility to systemic lupus erythematosus (SLE) …
factor-alpha (TNF-alpha) gene in susceptibility to systemic lupus erythematosus (SLE) …
Tumor necrosis factor-alpha gene polymorphism in psoriasis.
AI Arias, B Giles, TH Eiermann, W Sterry… - Experimental and …, 1997 - europepmc.org
Psoriasis, an inflammatory autoimmune disease, is characterized by increased level and
activity of the proinflammatory cytokine TNF-alpha in affected lesions. Two promoter region …
activity of the proinflammatory cytokine TNF-alpha in affected lesions. Two promoter region …
DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the …
SA Nedospasov, IA Udalova, DV Kuprash… - … (Baltimore, Md.: 1950 …, 1991 - journals.aai.org
TNF-alpha and lymphotoxin (LT, TNF-beta) genes are tandemly arranged and map within
the MHC centromeric to HLA-B and telomeric to the class III genes. Both cytokines encoded …
the MHC centromeric to HLA-B and telomeric to the class III genes. Both cytokines encoded …
A TNF-α promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis
T Höhler, A Kruger, PM Schneider, RE Schopf… - Journal of Investigative …, 1997 - Elsevier
Tumor necrosis factor-α is considered to be one of the important mediators in the
pathogenesis of psoriasis. A strong association of juvenile onset psoriasis with the major …
pathogenesis of psoriasis. A strong association of juvenile onset psoriasis with the major …
Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis.
B Mulcahy, F Waldron-Lynch… - American journal of …, 1996 - ncbi.nlm.nih.gov
The major histocompatibility complex class III tumor necrosis factor-lymphotoxin (TNF-LT)
region (6p21. 3) was investigated as a possible susceptibility locus for rheumatoid arthritis …
region (6p21. 3) was investigated as a possible susceptibility locus for rheumatoid arthritis …
Tumour necrosis factor 5′ promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis (RA) in immunogenetically defined multiplex RA …
F Waldron-Lynch, C Adams, C Amos, DK Zhu… - Genes & …, 2001 - nature.com
Tumour necrosis factor (TNF) plays a pivotal role in the pathogenesis of rheumatoid arthritis
(RA) and it has been shown that the TNF-lymphotoxin (TNF-LT) region influences …
(RA) and it has been shown that the TNF-lymphotoxin (TNF-LT) region influences …