Biosynthesis of tumor necrosis factor-α (TNF-α) is predominantly by cells of the monocytic
lineage. This study examined the role of various cis-acting regulatory elements in the …

Systemic lupus erythematosus (SLE) is a multisystem complex autoimmune disease of
uncertain etiology (OMIM 152700). Over recent years a genetic component to SLE …

Tumor necrosis factor alpha (TNF-alpha), a cytokine with pleiotropic biological effects, is
produced by a variety of cell types in response to induction by diverse stimuli. In this paper …

The regulation by tumor necrosis factor alpha (TNF) of its own promoter has been
investigated by transient transfection and nuclear protein binding assays. In human K652 …

Objective To determine whether tumor necrosis factor (TNF) polymorphisms are associated
with susceptibility to rheumatoid arthritis (RA) independently of the HLA–DR shared epitope …

The human tumor necrosis factor locus (TNF locus) is located within the major
histocompatibility complex between the class III genes and HLA-B. We recently …

We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor
necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE) …

Genes encoded on chromosome 6 within the major histocompatibility complex region are
thought to play an important role in the pathogenesis of psoriasis. A potential candidate …

Background A promoter polymorphism in the pro-inflammatory cytokine tumor necrosis
factor (TNF)(TNF G-308A) is associated with increased non-Hodgkin lymphoma (NHL) risk …

Genetic variation in cytokine promoter regions is postulated to influence susceptibility to
infection, but the molecular mechanisms by which such polymorphisms might affect gene …