The interaction of transcription factors is critical in the regulation of gene expression. This
study characterized the mechanism by which NF-κB family members interact to regulate the …

Tumor necrosis factor alpha (TNF-α) is an important mediator of inflammation, apoptosis,
and the development of secondary lymphoid structures. Multiple polymorphic microsatellites …

The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to
the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF …

Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that controls expression of
inflammatory genetic networks. Although the nuclear factor-κB (NF-κB) pathway is crucial for …

The human tumor necrosis factor alpha (TNF-α) gene is one of the earliest genes
transcribed after the stimulation of a B cell through its antigen receptor or via the CD40 …

OBJECTIVE: To investigate the association of tumor necrosis factor (TNF) promoter
polymorphisms with rheumatoid arthritis (RA) in Taiwan. METHODS: TNF promoter …

Variability in the structure of the human tumor necrosis factor (TNF-alpha) or lymphotoxin
(TNF-beta) genes may contribute to the functional polymorphism of the HLA gene complex …

Many insights have been gained into cytokine-regulated control of inflammatory processes
and host defence in recent years. Evidence has also gradually accumulated that cytokine …

The purpose of this work was to analyze the possible influence of TNF loci polymorphism on
the susceptibility and/or the disease profile of rheumatoid arthritis (RA). Tumor necrosis …

Transgenic mutagenesis in whole animals has become without doubt the most rewarding
approach to analyse gene structure, expression, and function. In the TNF field, much of what …