To explore mechanisms whereby unabsorbed nutrients in the ileum inhibit the upper gut ("
ileal brake"), we perfused the canine ileum or colon and monitored phase 3 in the …

We have previously described a negative feedback loop that inhibits duodenal motility when
nutrients are infused into the ileum and colon. In the present study, we examined the role of …

Peptide YY (PYY) antisecretory effect on intestinal epithelia is well established, whereas
less is known about its actions to influence colonic motility in conscious animals. We …

Slowing of intestinal transit by fat is abolished by immunoneutralization of peptide YY (PYY),
demonstrating a key role for this gut peptide. How PYY slows intestinal transit is not known …

Digestion and absorption of a meal are time-intensive processes. To optimize digestion and
absorption, transit of the meal through the gastrointestinal tract is regulated by a complex …

Peptide YY (PYY) and neuropeptide Y (NPY), infused into the quiescent isolated perfused
canine ileum, dose-dependently increased phasic activity of the circular muscle and …

BACKGROUND & AIMS: Fat in the distal gut inhibits transit through the proximal small
intestine as the ileal brake. Although the mediator of this response is not established …

Exposure of the ileum to nutrients markedly inhibits several upper gastrointestinal functions.
Hormonal peptides of the ileal wall, ie peptide YY (PYY), glucagon-like peptide-1 (GLP-1) …

Since feeding increases intestinal fluid and electrolyte losses in short bowel syndrome, an
agent increasing postprandial small bowel absorption might have a therapeutic role. Peptide …

To determine the effect of ileal oleate on fasting intestinal motility, pairs of duodenal and ileal
catheters and bipolar duodenal and jejunal seromuscular electrodes were surgically …