β-lactam therapeutic drug monitoring in critically ill patients: weighing the challenges and opportunities to assess clinical value
OBJECTIVE: β-lactams are the cornerstone of empiric and targeted antibiotic therapy for
critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug …
critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug …
The current status and future perspectives of beta-lactam therapeutic drug monitoring in critically Ill patients
E Novy, H Martinière, C Roger - Antibiotics, 2023 - mdpi.com
Beta-lactams (BL) are the first line agents for the antibiotic management of critically ill
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …
Does beta-lactam pharmacokinetic variability in critically ill patients justify therapeutic drug monitoring? A systematic review
FB Sime, MS Roberts, SL Peake, J Lipman… - Annals of intensive …, 2012 - Springer
The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …
Therapeutic drug monitoring of β-lactam antibiotics in the ICU
S Dhaese, S Van Vooren, J Boelens… - Expert review of anti …, 2020 - Taylor & Francis
Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes
while minimizing the risk of toxicity and antimicrobial therapy. β-lactam antibiotics are …
while minimizing the risk of toxicity and antimicrobial therapy. β-lactam antibiotics are …
Therapeutic drug monitoring of β-lactams in critically ill patients: proof of concept
JA Roberts, M Ulldemolins, MS Roberts… - International journal of …, 2010 - Elsevier
The extreme pharmacokinetic behaviour of drugs sometimes observed in critically ill patients
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …
The clinical application of beta-lactam antibiotic therapeutic drug monitoring in the critical care setting
Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam)
exposure due to alterations in their volume of distribution and elimination. Therapeutic drug …
exposure due to alterations in their volume of distribution and elimination. Therapeutic drug …
Barriers and facilitators in the clinical implementation of beta-lactam therapeutic drug monitoring in critically ill patients: a critical review
A Abdulla, P van den Broek, TMJ Ewoldt… - Therapeutic Drug …, 2022 - journals.lww.com
Background: With increasing knowledge of beta-lactam pharmacodynamics and interpatient
and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug …
and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug …
Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study
Background Beta-lactams (ie, penicillins, cephalosporins, carbapenems, monobactams) are
the most widely used class of antibiotics in critically ill patients. There is substantial …
the most widely used class of antibiotics in critically ill patients. There is substantial …
Update on therapeutic drug monitoring of beta-lactam antibiotics in critically ill patients—a narrative review
J Stašek, F Keller, V Kočí, J Klučka, E Klabusayová… - Antibiotics, 2023 - mdpi.com
Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …
Setting the beta-lactam therapeutic range for critically ill patients: is there a floor or even a ceiling?
OBJECTIVES: Beta-lactam antibiotics exhibit high interindividual variability in drug
concentrations in patients with critical illness which led to an interest in the use of …
concentrations in patients with critical illness which led to an interest in the use of …
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