Colon cancer is the third most common cancer and the second leading cause of cancer-
related death in the United States, emphasizing the need for the discovery of new cellular …

Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism
of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three …

Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important
paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death in the USA. It is of practical importance to identify novel therapeutic …

Arachidonic acid metabolism through cyclooxygenase (COX), lipoxygenase (LOX) and
cytochrome P-450 epoxygenase (EPOX) pathways leads to the generation of biologically …

Oxidative metabolism of polyunsaturated fatty acids has been linked to tumorigenesis in
general and colonic tumorigenesis in particular. Earlier studies showed that cyclooxygenase …

Enzymatic metabolism of the 20C polyunsaturated fatty acid (PUFA) arachidonic acid (AA)
occurs via the cyclooxygenase (COX) and lipoxygenase (LOX) pathways, and leads to the …

Oxidative stress is emerging as an important contributor to the pathogenesis of colorectal
cancer (CRC), however, the molecular mechanisms by which the disturbed redox balance …

Cytochrome P450-dependent ω-hydroxylation is a prototypic metabolic reaction of CYP4
family members that is important for the elimination and bioactivation of not only therapeutic …

Colorectal cancer (CRC) is one of the most serious complications of ulcerative colitis (UC).
Altered gut microbiota is implicated in the development of CRC and metabolic perturbations …