The biochemical paradigm for carbon monoxide (CO) is driven by the century-old Warburg
hypothesis: CO alters O2-dependent functions by binding heme proteins in competitive …

▪ Abstract The heme oxygenase (HO) system consists of two forms identified to date: the
oxidative stress–inducible protein HO-1 (HSP32) and the constitutive isozyme HO-2. These …

Heme oxygenase (HO) catalyzes the rate-limiting step in heme degradation, producing iron,
carbon monoxide, and bilirubin/biliverdin. HO consists of two isozymes: HO-1, which is an …

The ubiquitous gas, carbon monoxide (CO), is of substantial biological importance, but apart
from its affinity for reduced transition metals, particularly heme-iron, it is surprisingly …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …

Heme oxygenase (HO) and cyclooxygenase (COX) are two hemeproteins involved in the
regulation of several functions in the nervous system. Heme oxygenase is the enzyme …

(35). The two forms were shown to present different gene products with disparate
mechanisms of regulation and pattern of tissue distribution, with the adrenal glucocorticoids …

The HO-1 isoenzyme is an early stress response gene regulated by many forms of oxidative
stress. The HO-2 isoenzyme is predominantly a constitutive enzyme, which may serve to …

Heme oxygenase (HO) is believed to be a potent antioxidant enzyme in the nervous system;
it degrades heme from heme-containing proteins, giving rise to carbon monoxide, iron, and …

After traumatic brain injury (TBI), substantial extracellular heme is released from
hemoproteins during hemorrhage and cell injury. Heme oxygenase (HO) isozymes are …