A fragment-based development of 3C-triazol-1-yl-O-galactopyranosyl aldoximes led to the
discovery of highly selective and high affinity (Kd down to 11 μM) small monosaccharide …

A panel of anomeric oxime ether derivatives of β-galactose were synthesized via the
reaction of O-β-d-galactopyranosylhydroxylamine with aldehydes. The oxime ethers were …

Galactose C3-triazole derivatives were synthesized by Cu (I)-catalyzed cycloaddition
between acetylenes and galactose C3-azido derivatives. Evaluation against galectin-3, 7 …

As a result of our continued efforts to pursue Gal-3 inhibitors that could be used to fully
evaluate the potential of Gal-3 as a therapeutic target, two novel series of benzothiazole …

A new series of orally available α-d-galactopyranosides with high affinity and specificity
toward galectin-1 have been discovered. High affinity and specificity were achieved by …

1H-[1, 2, 3]-Triazol-1-yl mannosides have been synthesized as inhibitors for the β-
galactoside-binding family of galectin proteins. Easier synthetic access to C1 in mannose, as …

Galectins are galactoside-binding proteins that play a role in various pathophysiological
conditions, making them attractive targets in drug discovery. We have designed and …

This work describes the synthesis of the 1, 2, 3-triazole amino acid-derived-3-O-galactosides
1–6 and the 1, 2, 3-triazole di-lactose-derived glycoconjugate 7 as potential galectin-3 …

A strategy for generating potential galectin inhibitors was devised based on derivatization at
the C‐3′ atom in 3′‐amino‐N‐acetyllactosamine by using structural knowledge of the …

Inhibitors for galectin-1 and-3 were synthesized from thiodigalactoside and lactosamine by
derivatization of the galactose C3. Introduction of 4-phenyl-1 H-1, 2, 3-triazol-1-yl …