Differential DNA methylation of the hypothalamic‐pituitary‐adrenal axis related gene FKBP5
has recently been shown to be associated with varying response to environmental …

Background Hypothalamic–pituitary–adrenal (HPA) axis functioning has been implicated in
the development of stress‐related psychiatric diagnoses and response to adverse life …

Altered methylation of the FKBP5 gene has been observed in various mental disorders and
attributed to the effects of adverse childhood experiences (ACEs). However, the level of …

DNA methylation of the FKBP5 gene is assumed to alter FKBP5 expression and hence the
synthesis of the FK506 binding protein 51, a central element of a genomic negative …

Background: Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been
shown to influence glucocorticoid receptor sensitivity, stress response regulation, and …

Abstract Background FK506-binding protein 5 (FKBP5) binds to glucocorticoid receptors and
modulates glucocorticoid sensitivity. The FKBP5 gene has been implicated in the …

The FKBP5 gene codifies a co-chaperone protein associated with the modulation of
glucocorticoid receptor interaction involved in the adaptive stress response. The FKBP5 …

Background Child abuse is a risk factor for mood disorders, and linked to decreased DNA
methylation (DNAm) of FKBP5 intron 7 through interactions with the single nucleotide …

Exposure to childhood maltreatment increases the risk of developing mental illness later in
life. Childhood maltreatment and depression have both been associated with dysregulation …

The gene for the glucocorticoid receptor regulator FK506 binding protein 5 (FKBP5) plays a
role for risk, response to treatment, and changes in brain areas in major depressive disorder …