The objective of this hypothesis article is to review evidence supporting a role for calcium in
mediating ischemic brain damage, and to present data which puts mitochondrial dysfunction …

Background Preexposure of brain to isoflurane, a commonly used anesthetic, induces
ischemic tolerance. This phenomenon is called isoflurane preconditioning. However, it is not …

Background: Microdialysis with bedside biochemical analysis was used to monitor cerebral
biochemical alterations that precede and accompany increase in intracranial pressure (ICP) …

Neuronal death after ischemia-induced brain damage depends largely upon the activation
of the N-methyl-D-aspartate (NMDA) excitatory glutamate receptor that is a target for many …

Mitochondrial degradation is implicated in the irreversible cell damage that can occur during
cerebral ischemia and reperfusion. In this study, the effects of 10 min of ventricular fibrillation …

Background Barbiturates have previously been demonstrated to reduce focal cerebral
ischemic brain damage. However, the dose of drug required to elicit maximal …

Neurologic complications from cerebral ischemia occur frequently following cardiac arrest,
as well as in the perioperative period in cardiac surgery. The cellular and molecular …

Both in vitro and in vivo evidence supports the reduction of early ischemic, both global and
focal, brain injury by volatile anesthetics. However, the protection afforded by volatile …

Complete, reversible forebrain ischemia was induced with a seven-vessel occlusion rat
model. Previous studies of isehemic (MA Sciamanna, J. Zinkel, AY Fabi, and CP Lee, 1992 …

Transient global or forebrain ischemia leads to severe brain damage following delayed
neuronal cell death. We previously reported that cyclosporin A (CsA) provides near total …