Evading immune destruction and tumor promoting inflammation are important hallmarks in
the development of cancer. Macrophages are present in most human tumors and are often …

Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Macrophages have emerged as promising therapeutic targets in cancer. Within tumor tissue,
macrophages foster tumor development, invasion, and metastasis. As the phenotype of …

Macrophages are the most important phagocytes in vivo. However, the tumor
microenvironment can affect the function and polarization of macrophages and form tumor …

Tumor‐associated immune responses assert varied responses toward developing
neoplasms that can either act to eradicate malignant cells via engagement of potent …

The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal
cells and inhibitory immune cells counteracts the function of tumor reactive T cells. Tumor …

Macrophages are one of the most important cells in the innate immune system, they are
converted into two distinct subtypes with completely different molecular phenotypes and …

Tumor-associated macrophages are one of the major constituents of tumor stroma in many
solid tumors and there is compelling preclinical and clinical evidence that macrophages …

Simple Summary Innate and adaptive immunity mutually regulate one another in a dynamic
fashion during immune responses. In infectious contexts, positive interactions between …

Macrophages are widely distributed innate immune cells that play indispensable roles in the
innate and adaptive immune response to pathogens and in‐tissue homeostasis …