A breakthrough: macrophage-directed cancer immunotherapy
Successful immunotherapy of cancer is becoming a reality aided by the realization that
macrophages play an important role in the growth or regression of tumors. Specifically …
macrophages play an important role in the growth or regression of tumors. Specifically …
Instruction of myeloid cells by the tumor microenvironment: open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations
E Schouppe, P De Baetselier… - …, 2012 - Taylor & Francis
The versatility and plasticity of myeloid cell polarization/differentiation has turned out to be
crucial in health and disease, and has become the subject of intense investigation during …
crucial in health and disease, and has become the subject of intense investigation during …
Mitogen-activated protein kinase pathway: A critical regulator in tumor-associated macrophage polarization
T Neamatallah - Journal of Microscopy and Ultrastructure, 2019 - journals.lww.com
The notion that inflammation is a critical component of cancer has been researched
extensively. Tumor-associated macrophages (TAMs) are among the inflammatory cells that …
extensively. Tumor-associated macrophages (TAMs) are among the inflammatory cells that …
Interleukins in cancer: from biology to therapy
Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
Re-education of the tumor microenvironment with targeted therapies and immunotherapies
SF Ngiow, A Young - Frontiers in immunology, 2020 - frontiersin.org
The clinical success of cancer immunotherapies targeting PD-1 and CTLA-4 has ignited a
substantial research effort to improve our understanding of tumor immunity. Recent studies …
substantial research effort to improve our understanding of tumor immunity. Recent studies …
New insights into the role of macrophages in cancer immunotherapy
L Zhou, T Zhao, R Zhang, C Chen, J Li - Frontiers in immunology, 2024 - frontiersin.org
Macrophages are the main component of the tumor microenvironment, which are
differentiated from monocytes in the blood and play an important role in cancer …
differentiated from monocytes in the blood and play an important role in cancer …
Hijacked immune cells in the tumor microenvironment: molecular mechanisms of immunosuppression and cues to improve T cell-based immunotherapy of solid …
The understanding of the tumor microenvironment (TME) has been expanding in recent
years in the context of interactions among different cell types, through direct cell–cell …
years in the context of interactions among different cell types, through direct cell–cell …
Leukocyte infiltration in cancer creates an unfavorable environment for antitumor immune responses: a novel target for therapeutic intervention
V Bronte, S Cingarlini, I Marigo… - Immunological …, 2006 - Taylor & Francis
The interaction between tumor cells and the nearby environment is being actively
investigated to explore how this interplay affects the initiation and progression of cancer …
investigated to explore how this interplay affects the initiation and progression of cancer …
Metabolism and polarization regulation of macrophages in the tumor microenvironment
J Wang, S Mi, M Ding, X Li, S Yuan - Cancer letters, 2022 - Elsevier
The occurrence and development of tumors depend on the tumor microenvironment (TME),
which consists of various types of cellular and acellular components. Tumor-associated …
which consists of various types of cellular and acellular components. Tumor-associated …
Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion
JOA Van Ginderachter, K Movahedi, GH Ghassabeh… - Immunobiology, 2006 - Elsevier
Mononuclear phagocytes often function as control switches of the immune system, securing
the balance between pro-and anti-inflammatory reactions. For this purpose and depending …
the balance between pro-and anti-inflammatory reactions. For this purpose and depending …