In the aging brain, many of the alterations underlying cognitive and behavioral decline
remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a …

In the face of ever-changing cellular environments during life and ageing, the nervous
system ensures the coordination of behaviour and physiology. Over time, however, the …

It is often assumed, but not established, that the major neurodegenerative diseases, such as
Parkinson's disease, are not just age-dependent (their incidence changes with time) but …

The heterogeneity and multigenetic nature of nervous system aging make modeling of it a
formidable task in mammalian species. The powerful genetics, simple anatomy and short life …

Aging is characterized by a progressive decline in multiple physiological functions (ie,
functional aging). As animals age, they exhibit a gradual loss in motor activity, but the …

Aging of the nervous system underlies the behavioral and cognitive decline associated with
senescence. Understanding the molecular and cellular basis of neuronal aging will …

The aging process is inherently complex, involving multiple mechanisms that interact at
different biological scales. The nematode Caenorhabditis elegans is a simple model …

The ability to learn progressively declines with age. Neural hyperactivity has been
implicated in impairing cognitive plasticity with age, but the molecular mechanisms remain …

Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that
modulate healthy aging. In the aging nematode nervous system, neuronal death and/or …

Aging is characterized by general physiological decline over time. A hallmark of human
senescence is the onset of various age-related afflictions including neurodegeneration …