Nitric oxide (NO.) plays a central role in the physiology of the gastrointestinal tract and its
response to critical illness. Potential sources of NO. in the gut include: intrinsic intestinal …

There is growing evidence that endogenous nitric oxide (NO) regulates mucosal barrier
integrity under physiological conditions and counters the increase in mucosal permeability …

Inflammation of the intestinal tract remains a very serious concern in the clinical setting.
Unfortunately, to date, the mechanisms underlying many inflammatory conditions such as …

Nitric oxide (NO) plays important roles in gastrointestinal mucosal defence, as well as in the
pathogenesis of several gastrointestinal diseases (eg irritable bowel syndrome and …

Nitric oxide (NO) synthesis is markedly augmented in states of inflammation, largely due to
the expression of inducible nitric oxide synthase (iNOS). Although NO has anti-inflammatory …

Publisher Summary This chapter discusses some of the evidence and evolving concepts
that implicate Nitric Oxide (NO) as an antiinflammatory agent in the intestinal circulation. NO …

This article examines the evidence for nitric oxide (NO) as a protective agent in splanchnic
ischemia-reperfusion and other forms of acute intestinal inflammation. Four major points …

Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it
also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis …

The overall function of the gastrointestinal (GI) tract is to take up nutrients and remove waste.
The major physiologic processes that occur in the GI tract are motility, secretion, digestion …

We evaluated nitric oxide release in several models of intestinal inflammation through
luminal nitrite concentrations. In anesthetized rabbits, piglets, and guinea pigs, luminal …