MAPK signaling consists of an array of successively acting kinases. ERK1 and-2 (ERK1/2)
are major components of the greater MAPK cascade that transduce growth factor signaling …

Skeletal muscle regeneration is regulated by coordinated activation of multiple signaling
pathways. The unfolded protein response (UPR) is a major mechanism that detects and …

The Ras–extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway appears to be
important for the development, maintenance, aging, and pathology of mammalian skeletal …

Skeletal muscle is composed of diverse fiber types, yet the underlying molecular
mechanisms responsible for this diversification remain unclear. Herein, we report that the …

Understanding the fiber-type specification and metabolic switch in skeletal muscle provides
insights into energy metabolism in physiology and diseases. Here, we show that miR-182 is …

Treatment of Duchenne muscular dystrophy (DMD) by replacing mutant dystrophin or
restoring dystrophin‐associated glycoprotein complex (DAG) has been clinically …

The signal transduction cascades that maintain muscle mass remain to be fully defined.
Herein, we report that inhibition of extracellular signal-regulated kinase 1/2 (ERK1/2) …

Abstract Duchenne Muscular Dystrophy (DMD) originates from deleterious mutations in the
dystrophin gene, with a complete loss of the protein product [1, 2]. Subsequently, the …

The mitogen-activated protein kinase (MAPK)-activated protein kinases 2 and 3 (MK2/3)
represent protein kinases downstream of the p38 MAPK. Using MK2/3 double-knockout …

Activation of the Raf kinase signal transduction pathway in skeletal myoblasts causes a
complete cessation of myofiber formation and muscle gene expression. The negative …