Mesoporous silica nanoparticles with amino and thiol groups (MSNSN) were prepared and
covalently modified with methotrexate and 6-mercaptopurine to form 6-MP–MSNSN–MTX. In …

Mesoporous silica nanomaterials show great potential to deliver chemotherapeutics for
cancer treatment. The key challenges in the development of injectable mesoporous silica …

Purpose To investigate the effect of surface functionalization of mesoporous silica
nanoparticles (MSN) on crystallization, loading, release and activity of mitoxantrone (MTX) …

The objective of the study is to fabricate multifunctional mesoporous silica nanoparticles for
achieving co-delivery of conventional antitumor drug paclitaxel (PTX) and the multidrug …

We designed a novel cis-platin (CP) delivery system by modification of mesoporous silica
nanoparticle (MSN) surfaces with a carboxylate group through a hydrazone bond. The …

As efficient drug carriers, stimuli-responsive mesoporous silica nanoparticles are at the
forefront of research on drug delivery systems. An acid-responsive system based on silyl …

Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity
and large functionalizable surface area for target-directed delivery. In this study, a series of …

The development nano-carriers based therapeutic methods is a potent strategy for
enhancing cellular delivery of drugs and therapeutic efficiency in cancer chemotherapy. In …

Chemotherapy is an important anti-tumor treatment in clinic to date, however, the
effectiveness of traditional chemotherapy is limited by its poor selectivity, high systemic …

Targeted nanocarrier can selectively deliver anti-tumor drugs to cancer sites, improving drug
efficiency. Accordingly, a targeted nanocarrier (MSN-FA) was synthesized based on folic …