Suppression of neuropeptide by botulinum toxin improves imiquimod-induced psoriasis-like dermatitis via the regulation of neuroimmune system
SN Amalia, A Uchiyama, H Baral, Y Inoue… - Journal of …, 2021 - Elsevier
Background Psoriasis is a multifactorial disease arises from a complex interaction of
genetics, immune system, and environmental aspects. IL-23/Th17 immune axis has been …
genetics, immune system, and environmental aspects. IL-23/Th17 immune axis has been …
Effects of neuropeptides on Dendritic cells in the pathogenesis of psoriasis
J Zhang, S Zhao, X Xing, L Shang, J Cao… - Journal of Inflammation …, 2023 - Taylor & Francis
Psoriasis is an autoimmune disease that is characterized by discolored, scaled patches of
skin. Clinically, it is found that psychological factors often induce or aggravate the disease …
skin. Clinically, it is found that psychological factors often induce or aggravate the disease …
[HTML][HTML] Botulinum neurotoxin A decreases infiltrating cutaneous lymphocytes and improves acanthosis in the KC-Tie2 mouse model
NL Ward, KD Kavlick, D Diaconu… - The Journal of …, 2012 - ncbi.nlm.nih.gov
Psoriatic skin contains more nerve fibers (Naukkarinen et al., 1989), has increased levels of
sensory nerve-derived calcitonin gene related peptide (CGRP) and substance P (SP)(Chan …
sensory nerve-derived calcitonin gene related peptide (CGRP) and substance P (SP)(Chan …
CB2R deficiency exacerbates imiquimod-induced psoriasiform dermatitis and itch through the neuro-immune pathway
L Li, X Liu, W Ge, C Chen, Y Huang, Z Jin… - Frontiers in …, 2022 - frontiersin.org
Background: Cannabinoid receptor 2 (CB2R) is a potential target for anti-inflammatory and
pain therapeutics given its significant immunomodulatory and analgesic effects. However …
pain therapeutics given its significant immunomodulatory and analgesic effects. However …
Effects of tacrolimus ointment on the expression of substance P, nerve growth factor, and neurotrophin‐3 in atopic dermatitis
HO Kim, CH Lee, HK Ahn… - International journal of …, 2009 - Wiley Online Library
Background There is increasing evidence that neuropeptides may be involved in the
pathogenesis of atopic dermatitis (AD). Objectives To investigate the effects of tacrolimus on …
pathogenesis of atopic dermatitis (AD). Objectives To investigate the effects of tacrolimus on …
Dramatic effect of botulinum toxin type A on hypertrophic scar: A promising therapeutic drug and its mechanism through the SP-NK1R pathway in cutaneous …
S Zhang, K Li, Z Yu, J Chai, Z Zhang, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Hypertrophic scar formation may be related to cutaneous neurogenic
inflammation (CNI) through the substance P-neurokinin 1 receptor (SP-NK1R) signaling …
inflammation (CNI) through the substance P-neurokinin 1 receptor (SP-NK1R) signaling …
Neuronal changes in psoriasis exacerbation
H El‐Nour, A Santos, M Nordin… - Journal of the …, 2009 - Wiley Online Library
Background The nervous system contributes to inflammatory skin diseases. Objective The
aim of this investigation was to study the neuronal contribution to psoriasis at the remission …
aim of this investigation was to study the neuronal contribution to psoriasis at the remission …
[HTML][HTML] Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis
TC Chan, MS Lee, WC Huang, WY Chang… - Biomedicine & …, 2021 - Elsevier
Psoriasis is one of the most common chronic inflammatory diseases that is characterized by
well-defined erythematous plaques, with typical histopathological findings of lymphocytic …
well-defined erythematous plaques, with typical histopathological findings of lymphocytic …
The nerve injuries attenuate the persistence of psoriatic lesions
B Qin, C Sun, L Chen, S Wang, J Yang, Z Xie… - Journal of Dermatological …, 2021 - Elsevier
Background The involvement of the nerve in psoriasis development was suggested by
sporadic case reports. Objectives To provide multiple evidence for the nerve in psoriasis …
sporadic case reports. Objectives To provide multiple evidence for the nerve in psoriasis …
Impact of obesity on the IL-6 Immune marker and Th17 immune cells in C57BL/6 mice models with imiquimod-induced psoriasis
SH Park, KA Lee, JH Choi, SG Park, DW Kim… - International Journal of …, 2023 - mdpi.com
Obese psoriatic patients experience higher disease severity and exhibit poorer treatment
responses and clinical outcomes. It has been proposed that proinflammatory cytokines …
responses and clinical outcomes. It has been proposed that proinflammatory cytokines …