[HTML][HTML] Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis

TP Singh, MP Schön, K Wallbrecht… - PloS one, 2013 - journals.plos.org
It is thought that a Th1/Th17-weighted immune response plays a predominant role in the
pathogenesis of psoriasis. Our findings now indicate a link between IL-9, a Th2 and Th9 …

[HTML][HTML] Th1, Th17, and Treg responses are differently modulated by TNF-α inhibitors and methotrexate in psoriasis patients

SC Furiati, JS Catarino, MV Silva, RF Silva… - Scientific reports, 2019 - nature.com
Psoriasis is a chronic, recurrent, immune-mediated, hyperproliferative inflammatory skin
disease. The role of the adaptive immune system, particularly of Th1 and Th17 lymphocytes …

TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity

H Lu, Y Huang, X Ni, T Ma, T Chang… - Journal of the …, 2024 - Wiley Online Library
Background Psoriasis is an inflammatory skin disease. The pathogenesis of psoriasis has
not been fully elucidated. T‐lymphokine‐activated killer cell‐originated protein kinase …

Oral administration of a novel RORγt antagonist attenuates psoriasis-like skin lesion of two independent mouse models through neutralization of IL-17

M Takaishi, M Ishizaki, K Suzuki, T Isobe… - Journal of …, 2017 - Elsevier
Background Targeting the IL-17 pathway represents a highly effective strategy for the
treatment of psoriasis, using antibodies against IL-17A and IL-17 receptor, suggesting that …

Double‐labeled immunofluorescence study of cutaneous nerves in psoriasis

WY Jiang, SP Raychaudhuri… - International journal of …, 1998 - Wiley Online Library
Background and objective In recent years, many reports have suggested an active role of
neuropeptides in the pathogenesis of psoriasis. Increased numbers of neuropeptide …

RETRACTED: NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis

F Zhou, Z Zhu, J Gao, C Yang, L Wen, L Liu, X Zuo… - 2018 - Elsevier
RETRACTED: NFKB1 mediates Th1/Th17 activation in the pathogenesis of psoriasis -
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[HTML][HTML] Inhibition of Serum-and Glucocorticoid-Regulated Protein Kinase-1 Aggravates Imiquimod-Induced Psoriatic Dermatitis and Enhances Proinflammatory …

Q Meng, M Bai, M Guo, Z Li, W Liu, X Fan, R Sun… - Journal of Investigative …, 2023 - Elsevier
Although the anti-inflammatory effect of serum-and glucocorticoid-regulated protein kinase 1
(SGK1) has been established in other diseases, the possible regulatory role of SGK1 in …

[HTML][HTML] Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity

PKF Christensen, AK Hansen, S Skov, BC Martel… - Plos one, 2023 - journals.plos.org
Human immune system (HIS) mouse models can be valuable when cross-reactivity of drug
candidates to mouse systems is missing. However, no HIS mouse models of psoriasis have …

Topical glucocorticoid or pimecrolimus treatment suppresses thymic stromal lymphopoietin-related allergic inflammatory mechanism in an oxazolone-induced atopic …

NY Yoon, MY Jung, DH Kim, HJ Lee… - Archives of dermatological …, 2015 - Springer
Congenitally or early impaired skin barrier as the first event starting the 'atopic march'in
atopic dermatitis (AD) patients can increase allergen penetration that results in sensitization …

[HTML][HTML] Ozone therapy attenuates NF-κB-mediated local inflammatory response and activation of Th17 cells in treatment for psoriasis

J Zeng, L Lei, Q Zeng, Y Yao, Y Wu, Q Li… - … Journal of Biological …, 2020 - ncbi.nlm.nih.gov
Ozone therapy has been widely used to treat many skin diseases, including infections,
allergic dermatosis, and skin ulcers. However, its efficacy as a treatment for psoriasis is …