Dose-independent pharmacokinetics of digoxin in humans
HR Ochs, DJ Greenblatt, G Bodem, JS Harmatz - American heart journal, 1978 - Elsevier
Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …
Studies following intramuscular tritiated digoxin in human subjects
JE Doherty, WH Perkins - American Journal of Cardiology, 1965 - ajconline.org
Ten patients were digitalized by the intramuscular route with tritium-labeled digoxin.
Radioactivity levels of the serum, urine and stools were studied for seven days. Serum …
Radioactivity levels of the serum, urine and stools were studied for seven days. Serum …
Effect of cholestyramine on digoxin absorption and excretion in man
WH Hall, SD Shappell, JE Doherty - The American Journal of Cardiology, 1977 - Elsevier
Six subjects receiving digoxin therapy for heart disease were studied on two occasions with
a single oral dose of 0.5 mg of tritiated digoxin. In every study, all stools and urine were …
a single oral dose of 0.5 mg of tritiated digoxin. In every study, all stools and urine were …
Digoxin toxicity and electrolytes: a correlative study.
S Sundar, DP Burma, SK Vaish - Acta Cardiologica, 1983 - europepmc.org
Serum levels of sodium, potassium, calcium, magnesium and digoxin were studied in 67
patients on maintenance dose of digoxin, 42 with digitoxicity and 25 without. The mean …
patients on maintenance dose of digoxin, 42 with digitoxicity and 25 without. The mean …
Clinical value of serum digoxin assays in outpatients: improvement by the standardization of blood sampling
T Jogestrand, M Edner, M Haverling - American Heart Journal, 1989 - Elsevier
Everyday physical activity previously has been shown to affect serum digoxin
concentrations. Standardized rest in the supine position increases outpatient serum digoxin …
concentrations. Standardized rest in the supine position increases outpatient serum digoxin …
Digoxin pharmacokinetics in congestive heart failure
MM APPLEFELD, J ADIR… - The Journal of …, 1981 - Wiley Online Library
The steady‐state pharmacokinetics of oral digoxin in eight hospitalized patients was
compared upon their admission with marked right‐sided congestive heart failure and later …
compared upon their admission with marked right‐sided congestive heart failure and later …
Quantitation of digoxigenin in serum following oral administration of digoxin in humans.
JC Loo, IJ McGilveray, N Jordan - Research Communications in …, 1977 - europepmc.org
Separation of the acid breakdown products from digoxin in serum was accomplished by high
performance liquid chromatography (HPLC). The major, less cardioactive, product …
performance liquid chromatography (HPLC). The major, less cardioactive, product …
Myocardial and skeletal muscle concentrations of digoxin in patients on long-term therapy
J Coltart, M Howard, D Chamberlain - Br Med J, 1972 - bmj.com
The digoxin content was measured in samples of left ventricular papillary muscle, skeletal
muscle, and plasma obtained during mitral valve replacement from eight patients on …
muscle, and plasma obtained during mitral valve replacement from eight patients on …
The influence of verapamil on serum digoxin concentration.
HO Klein, R Lang, E Weiss, E Di Segni, C Libhaber… - Circulation, 1982 - Am Heart Assoc
The effect of verapamil on the pharmacokinetics of digoxin was studied in 49 patients with
chronic atrial fibrillation. A dose of 240 mg/day of verapamil was given to the patients who …
chronic atrial fibrillation. A dose of 240 mg/day of verapamil was given to the patients who …
A previously unrecognized drug interaction between quinidine and digoxin
JA Reiffel, EB Leahey Jr, RE Drusin… - Clinical …, 1979 - Wiley Online Library
Following the development of digoxin radioimmunoassay, we noted that serum digoxin
concentrations appeared to rise in patients given quinidine. To further evaluate this …
concentrations appeared to rise in patients given quinidine. To further evaluate this …