Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous
digoxin in a randomized three-way crossover study. Multiple venous blood samples were …

Ten patients were digitalized by the intramuscular route with tritium-labeled digoxin.
Radioactivity levels of the serum, urine and stools were studied for seven days. Serum …

Six subjects receiving digoxin therapy for heart disease were studied on two occasions with
a single oral dose of 0.5 mg of tritiated digoxin. In every study, all stools and urine were …

Serum levels of sodium, potassium, calcium, magnesium and digoxin were studied in 67
patients on maintenance dose of digoxin, 42 with digitoxicity and 25 without. The mean …

Everyday physical activity previously has been shown to affect serum digoxin
concentrations. Standardized rest in the supine position increases outpatient serum digoxin …

The steady‐state pharmacokinetics of oral digoxin in eight hospitalized patients was
compared upon their admission with marked right‐sided congestive heart failure and later …

Separation of the acid breakdown products from digoxin in serum was accomplished by high
performance liquid chromatography (HPLC). The major, less cardioactive, product …

The digoxin content was measured in samples of left ventricular papillary muscle, skeletal
muscle, and plasma obtained during mitral valve replacement from eight patients on …

The effect of verapamil on the pharmacokinetics of digoxin was studied in 49 patients with
chronic atrial fibrillation. A dose of 240 mg/day of verapamil was given to the patients who …

Following the development of digoxin radioimmunoassay, we noted that serum digoxin
concentrations appeared to rise in patients given quinidine. To further evaluate this …