The intestinal microbiota is a fundamental factor that broadly influences physiology. Thus,
studies using transgenic animals should be designed to limit the confounding effects of …

The gut microbiota is a complex ecosystem, affected by both environmental factors and host
genetics. Here, we aim at uncovering the bacterial taxa whose gut persistence is controlled …

Background Normal mammalian development and homeostasis are dependent upon the gut
microbiota. Antibiotics, essential for the treatment and prophylaxis of bacterial infections, can …

Horizontal transmission of the microbiota between different individuals is widely used to
normalize the microbiota in laboratory mice. However, little is known about the dynamics of …

Despite the fundamental contribution of the gut microbiota to host physiology, the extent of
its variation in genetically-identical animals used in research is not known. We report …

Background Murine models are a crucial component of gut microbiome research.
Unfortunately, a multitude of genetic backgrounds and experimental setups, together with …

Several associations have been made between characteristics of the resident gut microbiota
and human health and disease susceptibility. Animal models provide the means to test …

The mammalian gut harbors complex and variable microbial communities, across both host
phylogenetic space and conspecific individuals. A synergy of host genetic and …

In vertebrates, including humans, individuals harbor gut microbial communities whose
species composition and relative proportions of dominant microbial groups are …

Isobiotic mice, with an identical stable microbiota composition, potentially allow models of
host-microbial mutualism to be studied over time and between different laboratories. To …