Evolving models for assembling and shaping clathrin-coated pits
Clathrin-mediated endocytosis occurs via the assembly of clathrin-coated pits (CCPs) that
invaginate and pinch off to form clathrin-coated vesicles (CCVs). It is well known that adaptor …
invaginate and pinch off to form clathrin-coated vesicles (CCVs). It is well known that adaptor …
Hotspots organize clathrin‐mediated endocytosis by efficient recruitment and retention of nucleating resources
The formation of clathrin‐coated pits (CCPs) at the plasma membrane has been reported to
sometimes occur repeatedly at predefined sites. However, defining such CCP 'hotspots' …
sometimes occur repeatedly at predefined sites. However, defining such CCP 'hotspots' …
[HTML][HTML] De novo endocytic clathrin coats develop curvature at early stages of their formation
NM Willy, JP Ferguson, A Akatay, S Huber… - Developmental cell, 2021 - cell.com
Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation
on the cell surface, which is the primary function of the endocytosis machinery. Using super …
on the cell surface, which is the primary function of the endocytosis machinery. Using super …
Coupling between clathrin-coated-pit invagination, cortactin recruitment, and membrane scission observed in live cells
CJ Merrifield, D Perrais, D Zenisek - Cell, 2005 - cell.com
During clathrin-mediated endocytosis, membrane scission marks the isolation of a cargo-
laden clathrin-coated pit (CCP) from the cell exterior. Here we used live-cell imaging of a pH …
laden clathrin-coated pit (CCP) from the cell exterior. Here we used live-cell imaging of a pH …
Flat clathrin lattices: stable features of the plasma membrane
Clathrin-mediated endocytosis (CME) is a fundamental property of eukaryotic cells.
Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma …
Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma …
Phosphatidylinositol-(4, 5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size
Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in
mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin …
mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin …
Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2
Z Kadlecova, SJ Spielman, D Loerke… - Journal of Cell …, 2017 - rupress.org
The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and
when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which …
when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which …
Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles
O Kovtun, VK Dickson, BT Kelly, DJ Owen… - Science advances, 2020 - science.org
Clathrin-mediated endocytosis (CME) is crucial for modulating the protein composition of a
cell's plasma membrane. Clathrin forms a cage-like, polyhedral outer scaffold around a …
cell's plasma membrane. Clathrin forms a cage-like, polyhedral outer scaffold around a …
Molecularly distinct clathrin-coated pits differentially impact EGFR fate and signaling
R Pascolutti, V Algisi, A Conte, A Raimondi, M Pasham… - Cell Reports, 2019 - cell.com
Summary Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs).
Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian …
Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian …
Cell spreading area regulates clathrin-coated pit dynamics on micropatterned substrate
X Tan, J Heureaux, AP Liu - Integrative biology, 2015 - academic.oup.com
Clathrin-mediated endocytosis (CME) is the most characterized pathway for the endocytic
entry of proteins and lipids at the plasma membrane of eukaryotic cells. Numerous studies …
entry of proteins and lipids at the plasma membrane of eukaryotic cells. Numerous studies …