Adaptor protein complex 2 α and β-appendage domains act as hubs for the assembly of
accessory protein networks involved in clathrin-coated vesicle formation. We identify a large …

Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane
cargoes into transport vesicles that fuse with early endosomes. The process is responsive to …

The actin cytoskeleton has been implicated in the maintenance of discrete sites for clathrin‐
coated pit formation during receptor‐mediated endocytosis in mammalian cells, and its …

Although clathrin assembly by adaptor proteins (APs) plays a major role in the recycling of
synaptic vesicles, the molecular mechanism that allows APs to assemble clathrin is poorly …

Summary Clathrin/AP1-and clathrin/AP3-coated vesicular carriers originate from endosomes
and the trans-Golgi network. Here, we report the real-time visualization of these structures in …

Clathrin-mediated endocytosis (CME) is the major endocytosis pathway for the specific
internalization of large compounds, growth factors, and receptors. Formation of internalized …

During clathrin-mediated endocytosis, clathrin-coated pits invaginate to form clathrin-coated
vesicles (CVs). Since clathrin-coated pits are planar structures, whereas CVs are spherical …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and
their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to …

Because of the discovery of coated pits and vesicles more than 40 years ago and the
identification of clathrin as a major component of the coat, it has been assumed that clathrin …