Because of the discovery of coated pits and vesicles more than 40 years ago and the
identification of clathrin as a major component of the coat, it has been assumed that clathrin …

The ability of proteins to assemble at sites of high membrane curvature is essential to
diverse membrane remodeling processes, including clathrin-mediated endocytosis. Multiple …

The endocytic adaptor complex AP-2 colocalizes with the majority of clathrin-positive spots
at the cell surface. However, we previously observed that AP-2 is excluded from internalizing …

Eukaryotic cells utilize intricate mechanisms for the uptake and intracellular sorting of
various macromolecules, such as membrane components and extracellular proteins …

Assembly of clathrin lattices is mediated by assembly/adaptor proteins that contain domains
that bind lipids or membrane-bound cargo proteins and clathrin binding domains (CBDs) …

Clathrin-mediated endocytosis, the main trafficking route from the plasma membrane to the
cytoplasm, is critical to many fundamental cellular processes. Clathrin, coupled to the …

Clathrin-mediated endocytosis (CME) is the main route of internalization from the plasma
membrane. It is known that the heterotetrameric AP2 clathrin adaptor must open to …

Clathrin polymerization into a polyhedral vesicle coat drives receptor sorting at cellular
membranes during endocytosis and organelle biogenesis. To study clathrin self-assembly …

Background The notion that AP-2 clathrin adaptor is an essential component of an endocytic
clathrin coat appears to conflict with recent observations that substantial AP-2 depletion …

In diverse species, actin assembly facilitates clathrin-coated vesicle (CCV) formation during
endocytosis. This role might be an adaptation specific to the unique environment at the cell …