We have generalized the double nucleation mechanism of Ferrone et al.(Ferrone, FA, J.
Hofrichter, H. Sunshine, and WA Eaton. 1980. Biophys. J. 32: 361–377; Ferrone, FA, J …

The primary pathogenic event of sickle cell anemia is the polymerization of the mutant
hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the …

This paper outlines a theoretical formalism for describing the gelling behavior of sickle cell
hemoglobin in mixtures with other hemoglobin and non-hemoglobin proteins. Experimental …

The report by MF Colombo et al.(1) and the Perspective by RP Rand (2) state that a large
number of water molecules (about 60) take part in the allosteric regulation of human …

Abstract Models for the structure of the fibers of deoxy sickle cell hemoglobin (Hb S, β6
Glu→ Val) have been obtained from X‐ray and electron microscopic studies. Recent …

We have used the “osmotic stress” method to determine the phase diagram of
deoxyhemoglobin S polymerization. This method involves equilibration, through a …

We have monitored the growth of domains of sickle hemoglobin polymers by using
temporally and spatially resolved light scattering and birefringence measured …

We investigated the homogeneous nucleation and subsequent evolution of polymers of
sickle cell hemoglobin (HbS) using differential interference contrast (DIC) microscopy. The …

The software program, HINT (Hydropathic INTeractions), which characterizes non-polar-non-
polar, polar-polar, and non-polar-polar interactions, has been used to examine subunit …