Abstract Acute Rheumatic Fever (ARF) is the autoimmune condition triggered by untreated
Group A Streptococcal (GAS) infection of the upper respiratory tract (and possibly skin) …

Abstract Severe, invasive Streptococcus pyogenes (Strep A) infections result in greater than
500,000 deaths annually. First line treatment for such infections is benzylpenicillin, often with …

Aminoglycosides are often used to treat severe infections with gram-positive organisms.
Previous studies have shown concentration-dependent killing by aminoglycosides of gram …

Serum penicillin G falls to low levels 2 weeks after injection as benzathine penicillin G (BPG)
in young adults. Using Pmetrics and previously reported penicillin G pharmacokinetic data …

Introduction Regular intramuscular benzathine penicillin G injections have been the
cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As …

Background. People with a history of rheumatic fever (RF) are at high risk of recurrent
attacks and of developing rheumatic heart disease following a streptococcal throat infection …

Background: Activity of simulated serum concentrations after oral therapy with 400 mg
cefditoren pivoxil bid, 500 mg cefuroxime axetil bid and 875/125 mg amoxicillin/clavulanic …

Optimizing pharmacokinetic/pharmacodynamic indices of antibiotics to obtain clinical and
microbiological efficacy is essential, but dosing regimens must also be tailored to minimize …

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are preventable
complications of group A streptococcus (GAS) infection that is endemic in many countries …

The focus of antistreptococcal prophylaxis in the past 3 decades has been on the primary
and secondary prevention of rheumatic fever (RF) and rheumatic heart disease (RHD). Two …