Feathers and fins: non-mammalian models for hair cell regeneration

HR Brignull, DW Raible, JS Stone - Brain research, 2009 - Elsevier
Death of mechanosensory cells in the inner ear results in two profound disabilities: hearing
loss and balance disorders. Although mammals lack the capacity to regenerate hair cells …

The challenge of hair cell regeneration

AK Groves - Experimental Biology and Medicine, 2010 - journals.sagepub.com
Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …

A historical to present-day account of efforts to answer the question:“what puts the brakes on mammalian hair cell regeneration?”

JC Burns, JT Corwin - Hearing research, 2013 - Elsevier
Hearing and balance deficits often affect humans and other mammals permanently, because
their ears stop producing hair cells within a few days after birth. But production occurs …

Insights into sensory hair cell regeneration from the zebrafish lateral line

JS Kniss, L Jiang, T Piotrowski - Current opinion in genetics & development, 2016 - Elsevier
Loss of mechanosensory hair cells in the inner ear leads to loss of hearing. In humans this
results in permanent deafness, as mammals are largely unable to regenerate hair cells. In …

Sensory hair cell development and regeneration: similarities and differences

PJ Atkinson, E Huarcaya Najarro, ZN Sayyid… - …, 2015 - journals.biologists.com
Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

Hair cell regeneration

Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …

[HTML][HTML] Sensory hair cell death and regeneration in fishes

JD Monroe, G Rajadinakaran, ME Smith - Frontiers in cellular …, 2015 - frontiersin.org
Sensory hair cells are specialized mechanotransductive receptors required for hearing and
vestibular function. Loss of hair cells in humans and other mammals is permanent and …

Sensory hair cell regeneration in the zebrafish lateral line

ME Lush, T Piotrowski - Developmental Dynamics, 2014 - Wiley Online Library
Background: Damage or destruction of sensory hair cells in the inner ear leads to hearing or
balance deficits that can be debilitating, especially in older adults. Unfortunately, the …

A brief history of hair cell regeneration research and speculations on the future

EW Rubel, SA Furrer, JS Stone - Hearing research, 2013 - Elsevier
Millions of people worldwide suffer from hearing and balance disorders caused by loss of
the sensory hair cells that convert sound vibrations and head movements into electrical …

Hair cell regeneration: winging our way towards a sound future

O Bermingham-McDonogh, EW Rubel - Current opinion in neurobiology, 2003 - Elsevier
The discovery of hair cell regeneration in the inner ear of birds provides new optimism that
there may be a treatment for hearing and balance disorders. In this review we describe the …