THE IMPORTANCE OF REACTIVE OXYGEN SPECIES is well recognized in a number of
liver diseases, including inflammatory conditions. However, the molecular mechanisms have …

The liver plays a central role in the biotransformation of a variety of drugs and xenobiotics.
During the biotransformation of drugs and chemicals, the liver generates various reactive …

Under physiological conditions, intracellular and tissue levels of reactive oxygen species
(ROS) are carefully controlled and employed as fine modulators of signal transduction, gene …

Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …

The role of oxidative stress in causing liver diseases emerged in the early 1960s from the
laboratories of Trevor Slater, Mario Umberto Dianzani and others. These pioneering works …

This chapter describes the implication of oxidative stress in the progression of the liver
diseases with higher prevalence worldwide: nonalcoholic fatty liver disease, cholestasis …

Liver cell death induced by stresses such as ischemia‐reperfusion, cholestasis and drug
toxicity can trigger a sterile inflammatory response with activation of innate immune cells …

Livers generate low levels of reactive oxygen species (ROS), especially superoxide, in
mitochondria and hydrogen peroxide as normal function of various oxidases [1]. The large …

Oxidative stress and liver injury are strongly associated. Oxidative stress in the liver can be
triggered during different conditions and by specific etiologies, including hepatotoxins …

Oxidative stress is a major pathogenetic event occurring in several liver disorders ranging
from metabolic to proliferative ones, and is a major cause of liver damage due to …