Anti-fibrotic effects of Rhus javanica Linn (Anacardiaceae) extract against activated hepatic stellate cells via regulation of TGF-beta and smad signaling

SH Yoo, CJ Yoon, DH Kim, MJ Yum, JS Kim… - Tropical Journal of …, 2015 - ajol.info
Purpose: To evaluate the anti-fibrotic effects of ethanol extract of Rhus javanica
Linn.(Anacardiaceae)(RJE) in activated hepatic stellate cells (HSCs) as well as explore the …

[HTML][HTML] Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis

NM El-Lakkany, WH El-Maadawy, SHS El-Din… - Asian Pacific journal of …, 2017 - Elsevier
Objective To investigate the antifibrotic role of rosmarinic acid (RA), a natural polyphenolic
compound, on HSCs activation/proliferation and apoptosis in vitro and in vivo. Methods The …

[HTML][HTML] Chrysanthemum indicum ethanol extract attenuates hepatic stellate cell activation in vitro and thioacetamide-induced hepatofibrosis in rats

YJ Chae, S Koppula, MK Kim, T Yoon… - Asian Pacific Journal of …, 2021 - journals.lww.com
Objective: To investigate the antifibrotic effects of Chrysanthemum indicum ethanol extract
(CIEE) against activated hepatic stellate cells (HSC) and thioacetamide (TAA)-induced …

Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling

B Wu, L Huang, Y Wang, L Zeng, Y Lin, J Li… - Frontiers in …, 2022 - frontiersin.org
Ethnopharmacological relevance: Hepatic fibrosis (HF) occurs in response to chronic liver
injury and may easily develop into irreversible liver cirrhosis or even liver cancer. Amydrium …

Mitigation of TGF-β/Smad signaling pathway-associated liver fibrosis by paeoniflorin

WZ Li, ZB Wei - Tropical Journal of Pharmaceutical Research, 2017 - ajol.info
Purpose: To evaluate paeoniflorin (PF) as a possible protective agent against liver fibrosis
and its likely mechanisms of action. Methods: A rat model of liver fibrosis was induced by …

Rutin ameliorates hepatic fibrosis via targeting hepatic stellate cells' activation, proliferation and apoptosis

WH El-Maadawy, SH Seif el-Din, SM Ezzat… - Journal of Herbs …, 2021 - Taylor & Francis
Despite rutin, extracted from black mulberry, has several pharmacological activities, its exact
effect against hepatic fibrosis remains incompletely identified. Accordingly, this study …

Exploration of potential mechanism of Rougan formula against hepatic fibrosis by network analysis and experimental assessment

W Wang, Y Zhang, Y Jiang, Y Wang, J Zhu… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Rougan Formula (RG) has long been clinically
applied to treat hepatic fibrosis in patients with different chronic liver diseases. However, the …

Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling

J Li, B Wu, L Zeng, Y Lin, Q Chen, H Wang… - Frontiers in …, 2023 - frontiersin.org
Background: The present study aimed to investigate the protective effect of the water extract
of Amydrium sinense (Engl.) H. Li (ASWE) against hepatic fibrosis (HF) and clarify the …

Schisandra chinensis inhibiting TGFβ-induced activation of hepatic stellate cells

SY Shin, J Lee, HN Gil, YJ Jung, GL Kim… - Applied Biological …, 2018 - Springer
Hepatic fibrosis is one of the critical steps contained in the pathogenesis of liver cirrhosis.
Excessive deposition of collagen contributes to the development of fibrosis in chronic liver …

Asiaticoside conveys an antifibrotic effect by inhibiting activation of hepatic stellate cells via the Jagged-1/Notch-1 pathway

X Xiao, Q Zhang - Journal of Natural Medicines, 2023 - Springer
The aim of this study was to investigate the underlying protective mechanisms of
asiaticoside (AS) against liver fibrosis (LF) both in vivo and in vitro. A rat model with carbon …