OBJECTIVES: To compare neurodevelopmental outcomes in severe and moderate
congenital hypothyroidism (CH) among 3 different initial L-thyroxine doses and to examine …

Early detection by newborn screening and appropriate L-thyroxine treatment leads to normal
or near-normal neurocognitive outcome in infants with congenital hypothyroidism. Many …

Context The optimal levothyroxine (LT4) dose to treat congenital hypothyroidism (CH)
remains unclear, with debate over whether higher starting doses (> 10 µg/kg) are necessary …

Background: Optimal treatment of children with congenital hypothyroidism (CHT) is still
debated. Our objective was to evaluate whether early undertreatment (UT) and …

We aim to determine long-term intellectual outcome of adolescents with early high-dose
treated congenital hypothyroidism (CH). Sixty-three prospectively followed children with CH …

Background and aims: The optimal dose of thyroxine (T4) in congenital hypothyroidism (CH)
during infancy is controversial. Higher doses lead to improvement in cognitive scores, but …

Background: Despite newborn screening and early levothyroxine replacement, there are
continued reports of mild neurocognitive impairment in children with congenital …

Objectives: To test whether early treatment with a high initial dose of levothyroxine can
prevent suboptimal mental development in all neonates with congenital hypothyroidism …

Objective. To describe intellectual, motor, and school-associated outcome in young adults
with early treated congenital hypothyroidism (CH) and to study the association between long …

OBJECTIVES: To evaluate the influence of initial and postinitial treatment factors on
cognitive, psychomotor, and psychological outcome in schoolchildren with congenital …