Ceramide, an intracellular lipid mediator, is generated by transient hydrolysis of
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …

Pharmacological interference with sphingolipid metabolizing enzymes promises to provide
novel ways to modulate cellular pathways relevant in multiple diseases. In this review, we …

The sphingolipid ceramide is an important second messenger assumed to be involved in
fundamental processes, including proliferation, differentiation and growth arrest, as well as …

Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

Abstract Sphingosine, ceramide, sphingosine-1-phosphate, and other related sphingolipids
have emerged as important bioactive molecules involved in a variety of key cellular …

Sphingomyelin constitutes membrane microdomains such as lipid raft, caveolae, and
clathrin-coated pits and implicates in the regulation of trans-membrane signaling. On the …

Sphingolipids are not only structural components of biological membranes, but also play an
important role in cellular signalling and, thus, are involved in cell proliferation and …

Ceramide, a sphingosine-based lipid molecule, has emerged as a key regulator of a wide
spectrum of biological processes such as cellular differentiation, proliferation, apoptosis and …

Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and
sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An …