Colchicine is used chiefly in the treatment of gout but is also valuable in other inflammatory
diseases such as familial Mediterranean fever (FMF). Three proteins play pivotal roles in …

Objectives To review the literature and provide an update on the mechanisms of action and
therapeutic uses of oral colchicine in arthritis and inflammatory conditions. Methods We …

Colchicine is an ancient drug that is attracting renewed interest because of its actions at a
subcellular level. Specifically, it interferes with microtubule growth and therefore affects …

Colchicine is an antimitotic drug used to treat gout and familial Mediterranean fever.
Absolute bioavailability, pharmacokinetics, and absorption characteristics of colchicine after …

Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness
and its mode of action. Colchicine is mainly indicated for the treatment and prophylaxis of …

Colchicine (COL) has been used in medicine for a long time. It is well recognized as a valid
therapy in acute flares of gouty arthritis, familial Mediterranean fever (FMF), Behçet's …

OBJECTIVES: To review recent advances in the understanding of molecular mechanisms of
drug disposition and cellular mechanisms of action and targets of colchicine, and disease …

Colchicine is a tricyclic, lipid-soluble alkaloid derived from the plant of the Lily family
Colchicum autumnale, sometimes called the “autumn crocus”. It is predominantly …

OBJECTIVE:: To present an update of the use of colchicine in patients with familial
Mediterranean fever (FMF) and other rheumatic and nonrheumatic diseases. DATA …

New light has been shed on the mechanisms of action of colchicine in crystal-associated
arthropathies. Colchicine, long used to treat gout, arrests microtubule assembly and inhibits …