Identification of colorectal cancer related genes with mRMR and shortest path in protein-protein interaction network

BQ Li, T Huang, L Liu, YD Cai, KC Chou - PloS one, 2012 - journals.plos.org
One of the most important and challenging problems in biomedicine and genomics is how to
identify the disease genes. In this study, we developed a computational method to identify …

Identification of hepatocellular carcinoma related genes with k-th shortest paths in a protein–protein interaction network

M Jiang, Y Chen, Y Zhang, L Chen, N Zhang… - Molecular …, 2013 - pubs.rsc.org
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide and
one of the deadliest cancers in Asia. But at present, effective targets for HCC clinical therapy …

[HTML][HTML] Prioritization of potential candidate disease genes by topological similarity of protein–protein interaction network and phenotype data

J Luo, S Liang - Journal of biomedical informatics, 2015 - Elsevier
Identifying candidate disease genes is important to improve medical care. However, this task
is challenging in the post-genomic era. Several computational approaches have been …

Construction and comprehensive analysis of a molecular association network via lncRNA–miRNA–disease–drug–protein graph

ZH Guo, HC Yi, ZH You - Cells, 2019 - mdpi.com
One key issue in the post-genomic era is how to systematically describe the associations
between small molecule transcripts or translations inside cells. With the rapid development …

Identification of potential key genes and pathways in early-onset colorectal cancer through bioinformatics analysis

B Zhao, Z Baloch, Y Ma, Z Wan, Y Huo, F Li… - Cancer …, 2019 - journals.sagepub.com
This study was designed to identify the potential key protein interaction networks, genes,
and correlated pathways in early-onset colorectal cancer (CRC) via bioinformatics methods …

[HTML][HTML] Identification of potential biomarkers with colorectal cancer based on bioinformatics analysis and machine learning

A Hammad, M Elshaer, X Tang - Mathematical Biosciences and …, 2021 - aimspress.com
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Biomarker
discovery is critical to improve CRC diagnosis, however, machine learning offers a new …

Identification of key genes in colorectal cancer diagnosis by weighted gene co-expression network analysis

M Mortezapour, L Tapak, F Bahreini, R Najafi… - Computers in Biology …, 2023 - Elsevier
Background The purpose of this study was using bioinformatics tools to identify biomarkers
and molecular factors involved in the diagnosis of colorectal cancer, which are effective for …

Screening of hub genes and pathways in colorectal cancer with microarray technology

Y Wang, T Zheng - Pathology & Oncology Research, 2014 - Springer
Here we intend to identify key genes and pathways in the pathogenesis of colorectal cancer
(CRC) through analyzing microarray data with bioinformatic tools. The gene expression …

Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer

C Chen, H Shen, LG Zhang, J Liu… - International …, 2016 - spandidos-publications.com
Currently, using human prostate cancer (PCa) tissue samples to conduct proteomics
research has generated a large amount of data; however, only a very small amount has …

A comparative study of cancer proteins in the human protein-protein interaction network

J Sun, Z Zhao - BMC genomics, 2010 - Springer
Background Cancer is a complex disease. So far, many genes have been reported to
involve in the development of cancer. Rather than the traditional approach to studying …