The mixture of cytokines that is produced in the tumour microenvironment has an important
role in cancer pathogenesis. Cytokines that are released in response to infection …

The concept that the immune system recognizes and controls cancer was first postulated
over a century ago, and cancer immunity has continued to be vigorously debated and …

Simple Summary Cytokines are important molecular players in cancer development,
progression, and potential targets for treatment. Despite being small and overlooked …

Cytokines are molecular messengers that allow the cells of the immune system to
communicate with one another to generate a coordinated, robust, but self-limited response …

The epithelial tumour microenvironment is a complex tissue comprising variable numbers of
tumour cells, fibroblasts, endothelial cells and infiltrating leucocytes. Cytokines are key …

During the past 40 years, cytokines and cytokine receptors have been extensively
investigated as either cancer targets or cancer treatments. A strong preclinical rationale …

Cytokines such as IL-1 and TNF are primarily pro-inflammatory. The inflammation induced
by these cytokines is reflected in the type of genes they induce. In the pathogenesis of …

In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …

Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the
discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal …

The human body combats infection and promotes wound healing through the remarkable
process of inflammation. Inflammation is characterized by the recruitment of stromal cell …