The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage
specification and differentiation. To gain insight into the molecular basis of Ebf1 function in …

Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis
and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional …

The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain
insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally …

During the last decades, many studies have investigated the transcriptional and epigenetic
regulation of lineage decision in the hematopoietic system. These efforts led to a model in …

Hematopoiesis is regulated by signals from the microenvironment, transcription factor
networks, and changes of the epigenetic landscape. Transcription factors interact with and …

B-cell fate determination requires the action of transcription factors that operate in a
regulatory network to activate B-lineage genes and repress lineage-inappropriate genes …

Early B-cell factor (EBF) is a DNA-binding protein required for B-cell lymphopoiesis. The lack
of EBF results in an early developmental blockade, including the lack of functional B cells …

B lymphocytes are generated from hematopoietic stem cells in a series of steps controlled by
transcription factors. One of the most important regulators of this process is early B cell factor …

Lymphopoiesis requires the activation of lineage-specific genes embedded in naive,
inaccessible chromatin or in primed, accessible chromatin. The mechanisms responsible for …

The transcription factor EBF1 is essential for lineage specification in early B cell
development. In this study, we demonstrate by conditional mutagenesis that EBF1 is …