Progressive DNA damage and mitochondrial decline are both considered to be prime
instigators of natural ageing. Traditionally, these two pathways have been viewed largely in …

Telomerase plays an important role in cellular proliferation capacity and survival under
conditions of stress. A large part of this protective function is due to telomere capping and …

Telomerase is often re‐activated in human cancers and is widely used to immortalize cells in
culture. In addition to the maintenance of telomeres, telomerase has been implicated in cell …

Telomerase activity is essential for human cancer cells in order to maintain telomeres and
provide unlimited proliferation potential and cellular immortality. However, additional non …

The attrition of telomeres is believed to be a key event not only in mammalian aging, but also
in disturbed nutrient sensing, which could lead to numerous metabolic dysfunctions. The …

Telomeres are dynamic chromosome-end structures that serve as guardians of genome
stability. They are known to be one of the major determinants of aging and longevity in …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Telomerase has cellular functions beyond telomere stabilization, including a role in
mitochondria. The function of the catalytic component—TERT—in mitochondria is still …

Studies in humans and in mice have highlighted the importance of short telomeres and
impaired mitochondrial function in driving age-related functional decline in the heart …

Telomeres in telomerase-negative cells shorten during DNA replication in vitro due to
numerous causes including the inability of DNA polymerases to fully copy the lagging …